Molecular Farming Using Bioreactor-Based Plant Cell Suspension Cultures for Recombinant Protein Production
- Ting-Kuo HuangAffiliated withDepartment of Chemical Engineering and Materials Science, University of California – Davis
- , Karen A. McDonaldAffiliated withDepartment of Chemical Engineering and Materials Science, University of California – Davis Email author
The need for biomanufacturing capacity for recombinant protein production to meet the expanding pharmaceutical and industrial market demands has gained increasing importance, leading to the development of new protein expression platforms capable of addressing requirements in terms of protein yield, product quality, and production cost. In the past few decades, molecular farming using plant cell-based expression systems (whole plants and in vitro plant cells, organ and tissue cultures) have been investigated as an alternative for the large-scale bioproduction of recombinant proteins. Molecular farming using bioreactor-based plant cell suspension cultures provides attractive features over recombinant microbial fermentation and mammalian cell cultures in terms of intrinsic safety, cost-effective biomanufacturing, and the capability for post-translation modifications. The current research and development, emerging techniques, commercialization and future prospects of molecular farming using bioreactor-based plant cell suspension cultures for production of recombinant proteins will be discussed in this chapter.
- Molecular Farming Using Bioreactor-Based Plant Cell Suspension Cultures for Recombinant Protein Production
- Book Title
- Molecular Farming in Plants: Recent Advances and Future Prospects
- pp 37-67
- Print ISBN
- Online ISBN
- Springer Netherlands
- Copyright Holder
- Springer Science+Business Media B.V.
- Additional Links
- Industry Sectors
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- Editor Affiliations
- ID1. Agriculture and Agri-Food Canada
- ID2. , Immunology and Transplantation, Lawson Health Research Institute/Plantig
- Author Affiliations
- 1. Department of Chemical Engineering and Materials Science, University of California – Davis, 1031B Kemper Hall, 1 Shields Avenue, Davis, CA, 95616, USA
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