Interplay between Metal Ions and Nucleic Acids

Volume 10 of the series Metal Ions in Life Sciences pp 249-268


Enantioselective Catalysis at the DNA Scaffold

  • Almudena García-FernándezAffiliated withStratingh Institute for Chemistry, University of Groningen
  • , Gerard RoelfesAffiliated withStratingh Institute for Chemistry, University of Groningen Email author 

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The unique chiral structure and the highly specific Watson-Crick base-pairing interactions that characterize natural double-stranded DNA, make this natural biopolymer an attractive ligand for asymmetric catalytic processes. In this chapter the applications of DNA as scaffold and chiral ligand in enantioselective transition metal catalysis are presented. An overview of the state of the art for the different approaches to metal-DNA based catalysts is given, followed by an overview of the mechanistic studies that have been performed to date.


asymmetric catalysis chirality DNA DNA-based catalysis reactions in water