Chapter

Interplay between Metal Ions and Nucleic Acids

Volume 10 of the series Metal Ions in Life Sciences pp 119-134

Date:

G-Quadruplexes and Metal Ions

  • Nancy H. CampbellAffiliated withCRUK Biomolecular Structure Group, The School of Pharmacy, University of London
  • , Stephen NeidleAffiliated withCRUK Biomolecular Structure Group, The School of Pharmacy, University of London Email author 

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Abstract

Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex. Three categories of quadruplex are examined, tetramolecular, bimolecular, and intramolecular: all are formed by telomeric nucleic acid sequences from human or ciliate organisms.

Keywords

crystal structures ion channel metal ion coordination Protein Data Bank quadruplex