Interplay between Metal Ions and Nucleic Acids

Volume 10 of the series Metal Ions in Life Sciences pp 103-118


Metal Ion-Promoted Conformational Changes of Oligonucleotides

  • Bernhard SpinglerAffiliated withInstitute of Inorganic Chemistry, University of Zürich Email author 

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The review will discuss the influence of metal ions on conformational changes of oligonucleotides. First, a short definition of the torsion angles is given, followed by a concise yet critical overview of the commonly applied experimental techniques. Finally, the possible role of metals upon the following conformational changes of oligonucleotides is discussed: (i) the denaturation of double-strands, (ii) the transition from B- to A-DNA, (iii) the transition from right- to left-handed DNA and RNA, (iv) the condensation, (v) and other conformational changes. We conclude with a summary and outlook.


circular dichroism conformational change crystal structure DNA metal RNA