Chapter

Interplay between Metal Ions and Nucleic Acids

Volume 10 of the series Metal Ions in Life Sciences pp 319-340

Date:

Metal Complex Derivatives of Peptide Nucleic Acids (PNA)

  • Roland KrämerAffiliated withInorganic Chemistry Institute, University of Heidelberg Email author 
  • , Andriy MokhirAffiliated withInorganic Chemistry Institute, University of Heidelberg

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Abstract

Peptide nucleic acid (PNA) is a non-cyclic pseudopeptide-nucleic acid structural mimic with promising applications within diagnostics and drug discovery. This review focuses on metal complex derivatives of PNA. Metal ions and their complexes display unique physical and chemical properties and offer the opportunity to introduce new labels and probes for bioanalytical and diagnostic applications of PNA, but also to modulate or to introduce new (for example catalytic) functions and biological activities.

Keywords

cellular uptake labels metal complexes nucleic acid detection peptide nucleic acids