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Transient Receptor Potential Channels pp 707–729Cite as

TRPM Channels in the Vasculature

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 704))

Abstract

Recent studies show that mammalian melastatin TRPM nonselective cation channels (TRPM1-8), members of the largest and most diverse TRP subfamily, are widely expressed in the endothelium and vascular smooth muscles. When activated, these channels similarly to other TRPs permit the entry of sodium, calcium and magnesium, thus causing membrane depolarisation. Although membrane depolarisation reduces the driving force for calcium entry via TRPMs as well as other pathways for calcium entry, in smooth muscle myocytes expressing voltage-gated Ca2+ channels the predominant functional effect is an increase in intracellular Ca2+ concentration and myocyte contraction. This review focuses on several best documented aspects of vascular functions of TRPMs, including the role of TRPM2 in oxidant stress, regulation of endothelial permeability and cell death, the connection between TRPM4 and myogenic response, significance of TRPM7 for magnesium homeostasis, vessel injury and hypertension, and emerging evidence that the cold and menthol receptor TRPM8 is involved in the regulation of vascular tone.

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Abbreviations

CA:

constitutively active

CaM:

calmodulin

CAN:

Ca2+-activated nonselective channel

DAG:

diacylglycerol

EC:

endothelial cell

GPCR:

G protein-coupled receptor

InsP3 :

inositol 1,4,5-trisphosphate

lysoPL:

lysophospholipids

NSCC:

non-selective cation channel

PIP2 :

phosphatidylinositol-4,5-bisphosphate

PKA:

protein kinase A

PKC:

protein kinase C

PLC:

phospholipase C

ROC:

receptor-operated channel

ROS:

reactive oxygen species

SAC:

stretch-activated channel

SOC:

store-operated channel

SR:

sarcoplasmic reticulum

TM:

transmembrane domain

VGCC:

voltage-gated Ca2+ channels

VSMC:

vascular smooth muscle cell

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Acknowledgments

Research in the authors’ laboratories is funded by BHF and NIH. We thank Mrs Tetyana Zholos for her assistance in the preparation of this review.

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Authors and Affiliations

  1. Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Sciences, Royal Victoria Hospital, Queen’s University of Belfast, Belfast, BT12 6BA, UK

    Alexander Zholos & Donal Melanaphy

  2. Centre for Biomedical Science Education, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University of Belfast, Belfast, BT9 7BL, UK

    Christopher Johnson

  3. Department of Physiology, University of Liverpool, L69 3BX, Liverpool, UK

    Theodor Burdyga

Authors
  1. Alexander Zholos
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  2. Christopher Johnson
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  3. Theodor Burdyga
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  4. Donal Melanaphy
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Correspondence to Alexander Zholos .

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Editors and Affiliations

  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

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Zholos, A., Johnson, C., Burdyga, T., Melanaphy, D. (2011). TRPM Channels in the Vasculature. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_37

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