Date: 20 Dec 2009

Telomeres and Telomerase

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Abstract

Telomere-based replicative senescence is thought to function as a potent mechanism of tumor protection in humans. Whether this mechanism is conserved in other species is still unclear. In this review we present an inter-species critical overview of some of the available literature on the fundamental biology of telomeres and telomerase during development, regeneration, cancer and aging of living organisms during their evolutionary journey through time.

N.M.V. Gomes has been co-supported by the European Union Programs POCI 2010 & FSE and by national funds from the Portuguese Ministry for Science, Technology and Superior Education (SFRH/BD/8826/2002). Also supported by the Keck Foundation.