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Heat Shock Proteins and Whole Body Physiology

Volume 5 of the series Heat Shock Proteins pp 351-364

Date:

Molecular Chaperones as Mediators of Stress Protective Effect of Plant Adaptogens

  • Alexander PanossianAffiliated withSwedish Herbal Institute Research and DevelopmentSwedish Herbal Institute Research and Development
  • , Georg WikmanAffiliated withSwedish Herbal Institute Research and Development
  • , Punit KaurAffiliated withDivision of Investigative Pathology, The Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and Clinic
  • , Alexzander AseaAffiliated withDivision of Investigative Pathology, The Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and Clinic

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Abstract

The ability of plant adaptogens to enhance the “state of non-specific resistance” of an organism to stress by augmenting resistance to physical, biological, chemical and psychological stresses, and increasing concentration, performance and endurance during fatigue have placed it in a unique position among medicinal plants. However, the molecular mechanism by which plant adaptogens exerts its beneficial effects is thus far incompletely understood. This chapter focuses on recent advances in the understanding the molecular mechanism exerted by ADAPT-232 forte, a plant adaptogens consisting of a fixed combination of three extracts of Eleutherococcus senticocus, Schisandra chinensis and Rhodiola rosea. Our studies suggest that ADAPT-232 exerts its beneficial effect, in part, by a mechanism dependent on the upregulation of Hsp70 expression. A concise discussion of the effect of adaptogens on endurance and a comparison of hormetins and adaptogens will also be discussed

Keywords:

Adaptogens Eleutherococcus senticocus heat shock proteins hormesis longevity Rhodiola rosea Schisnadra chinesis