Summary
With the aim of developing a high-performance membrane-type artificial lung, a novel silicon-containing hydrophilic-hydrophobic block copolymer was prepared using a living anionic polymerization technique. To introduce high oxygen permeability, poly(4-[bis (trimethylsilyl)methyl)styrene]) [poly(BSMS)] was employed for the hydrophobic segment. Poly(2-hydroxyethyl methacrylate) [poly(HEMA)] segment was chosen as a counterpart to maintain high blood compatibility. A poly(BSMS-block-HEMA) [BH(X), where X denotes the mole fraction of BSMS in the copolymer] membrane showed a clear separation of microphase structure when the mole fraction X was more than 30% (cast from toluene solution), while BH(10) showed no marked phase separation, when the respective polymer was cast from a dimethylformamide (DMF) solution. It should be noted that DMF is a poor solvent for the poly(BSMS) segment. From a dynamic light scattering measurement of a DMF solution of BH(10) (0.1% w/v), submicron-sized particles were observed. The BH(10) surface prepared from this DMF solution containing submicron particles showed unique characteristics. The wettability of the BH(10) membrane was much higher than that of the poly(HEMA) surface, despite the introduction of the hydrophobic polymer segment. The equilibrium water content of the BH(10) was also higher than that of poly (HEMA). This may be explained by the supramolecular structure of the BH(10) membrane derived from the particle-casting technique. Also surprising was that the BH(10) surface showed extremely high blood compatibility. Indeed, the rate of adhesion and activation of rabbit platelets on the surface was much lower than on poly(styrene-block-HEMA), which we have shown to have fairly high blood compatibility. From these results, it can be concluded that BH(10) is a promising candidate for a novel blood-compatible material for use in such applications as an artificial lung and as a nonthrombogenic coating material.
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References
Terasaki H, Morioka T (1991) Extracoporeal lung and heart assist with the artificial membrane lung in Japan. Artif Organs Today 1:115–127
Weathersby PK, Kolobow T, Stool EW (1975) Relative thrombogenicity of polydimethylsiloxane and silicone rubber constituents. J Biomed Mater Res 9:561–568
Braley S (1970) The chemistry and properties of the medical-grade silicones. J Macromol Sci Chem A4:529–544
Ito H, Taenaka A, Nagasaki Y, Kataoka K, Kato M, Tsuruya T (1996) Silicon-containing block copolymer membranes. Polymer 37:633–637
Okano T, Nishiyama S, Shinohara I, Akaike T, Sakurai Y, Kataoka K, Tsuruta T (1981) Effect of hydrophilic and hydrophobic microdomains on mode of interaction between block polymer and blood plateletes. J Biomed Mater Res 15:393–402
Nagasaki Y, Tsuruta T (1986) A novel synthesis of styrene derivatives with silylmethyl groups. Makromol Chem Rapid Commun 7:437–439
Tingy KG, Ardrade JD, Mcgary CW Jr, Zdrahata RJ (1988) The contact angle and interface energetics. In: Andrade JD (ed) Polymer surface dynamics. Plenum, New York, pp 105–118
Grynkiewicz G, Poenie M, Tsien RY (1985) A new generation of Ca2+indicators with greatly improved fluoresence properties. J Biol Chem 260:3440–3448
Rink TJ, Smith SW, Tsien RY (1982) Cytoplasmic free Ca2+in human platelets: Ca2+thresholds and Ca-independent activation for shape-change and secretion. FEBS Lett 148:21–26
Ito H, Nagasaki Y, Kataoka K, Kato M, Tsuruta T, Suzuki K, Okano T, Sakurai Y (1997) Molecular design of poly(HEMA) brushes and its blood compatibility. Jpn J Anif Organs 16:519–523
Iwasaki Y, Fujike A, Kurita K, Ishihara K, Nakabayashi N (1996) Protein adscrption and platelet adhesion on polymer surfaces having phospholipid polar group connected with oxyethylene chain. J Biomater Sci Polym Ed 8:91–102
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© 1998 Springer-Verlag Tokyo
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Ito, H. et al. (1998). Highly Blood-Compatible Surface Consisting of a Silicon-Containing Block Copolymer with Supramolecular Structure. In: Akutsu, T., Koyanagi, H. (eds) Heart Replacement. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65921-1_21
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DOI: https://doi.org/10.1007/978-4-431-65921-1_21
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-65923-5
Online ISBN: 978-4-431-65921-1
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