Chapter

Molecular, Clinical and Environmental Toxicology

Volume 101 of the series Experientia Supplementum pp 315-360

Date:

Male Reprotoxicity and Endocrine Disruption

  • Sarah CampionAffiliated withDepartment of Pathology and Laboratory Medicine, Brown University
  • , Natasha CatlinAffiliated withDepartment of Pathology and Laboratory Medicine, Brown University
  • , Nicholas HegerAffiliated withDepartment of Pathology and Laboratory Medicine, Brown University
  • , Elizabeth V. McDonnellAffiliated withDepartment of Pathology and Laboratory Medicine, Brown University
  • , Sara E. PachecoAffiliated withDepartment of Pathology and Laboratory Medicine, Brown University
  • , Camelia SaffariniAffiliated withDepartment of Pathology and Laboratory Medicine, Brown University
  • , Moses A. SandrofAffiliated withDepartment of Pathology and Laboratory Medicine, Brown University
  • , Kim BoekelheideAffiliated withDepartment of Pathology and Laboratory Medicine, Brown University Email author 

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Abstract

Mammalian reproductive tract development is a tightly regulated process that can be disrupted following exposure to drugs, toxicants, endocrine-disrupting chemicals (EDCs), or other compounds via alterations to gene and protein expression or epigenetic regulation. Indeed, the impacts of developmental exposure to certain toxicants may not be fully realized until puberty or adulthood when the reproductive tract becomes sexually mature and altered functionality is manifested. Exposures that occur later in life, once development is complete, can also disrupt the intricate hormonal and paracrine interactions responsible for adult functions, such as spermatogenesis. In this chapter, the biology and toxicology of the male reproductive tract is explored, proceeding through the various life stages including in utero development, puberty, adulthood, and senescence. Special attention is given to the discussion of EDCs, chemical mixtures, low-dose effects, transgenerational effects, and potential exposure-related causes of male reproductive tract cancers.

Keywords

Androgen insensitivity syndrome Bisphenol A Chemical mixtures Cryptorchidism Diethylstilbestrol Endocrine-disrupting chemicals Hypospadias Low-dose effects Phthalates Testicular dysgenesis syndrome Testicular germ cell tumors Transgenerational effects Vinclozolin