Chapter

Synaptic Plasticity

Volume 970 of the series Advances in Experimental Medicine and Biology pp 451-468

Date:

Synaptic Pathology of Down Syndrome

  • Craig C. GarnerAffiliated withDepartment of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University School of Medicine Email author 
  • , Daniel Z. WetmoreAffiliated withDepartment of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University School of Medicine

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Abstract

Down syndrome is characterized by mild to moderate cognitive impairments that are caused by trisomy of chromosome 21. Several anatomical, behavioral, electrophysiological, and developmental abnormalities have been associated with Down syndrome. In this review, the current knowledge about the neurobiology of this disease and future perspectives of pharmacological treatments for this condition will be discussed.

Keywords

Developement Pharmacotherapy Spinogenesis Trisomie 21 Ts65Dn mice