Chapter

Intracerebral Hemorrhage Research

Volume 111 of the series Acta Neurochirurgica Supplementum pp 145-149

Date:

The Neuroprotective Effects of Cyclooxygenase-2 Inhibition in a Mouse Model of Aneurysmal Subarachnoid Hemorrhage

  • R. AyerAffiliated withDepartment of Neurosurgery, Loma Linda University Medical Center
  • , V. JadhavAffiliated withDepartment of Physiology and Pharmacology, Loma Linda University Medical Center
  • , T. SugawaraAffiliated withDepartment of Physiology and Pharmacology, Loma Linda University Medical Center
  • , John H. ZhangAffiliated withDepartment of Neurosurgery, Loma Linda University Medical CenterDepartment of Physiology and Pharmacology, Loma Linda University Medical CenterDepartment of Anesthesiology, Loma Linda University Medical CenterDepartment of Neurosurgery, Loma Linda University Medical Center Email author 

* Final gross prices may vary according to local VAT.

Get Access

Abstract

The CNS inflammatory reaction occurring after aneurysmal subarachnoid hemorrhage (SAH) involves the upregulation of numerous cytokines and prostaglandins. Cyclooxygenase (COX) inhibition is a well-established pharmacological anti-inflammatory agent. Previous studies have shown marked increases in COX-2 expression in neurons, astrocytes, microglia, and endothelial cells following brain injury. COX-2 inhibition has been shown to be beneficial following various types of brain injury. This experiment investigates the role of COX-2 activity in early brain injury following SAH. CD-1 mice were subjected to an endovascular perforation model of SAH or SHAM surgery. Following experimental SAH animals were treated with the specific COX-2 inhibitor, NS398, in dosages of either 10 or 30 mg/kg. Neurological performance and brain edema were evaluated 24 and 72 h after SAH. NS398 at 30 mg/kg significantly reduced SAH-induced neurological deterioration. NS 398 at 30 mg/kg resulted in a trend toward the reduction of SAH-induced cerebral edema. Treatment had no effect on mortality. This experiment provides preliminary evidence that COX-2 inhibition is an effective pharmacological intervention for the prevention of brain edema and the preservation of neurological function following SAH.

Keywords

Aneurysmal subarachnoid hemorrhage · Early brain injury · Cyclooxygenase inhibition · COX-2 · Cerebral edema