Chapter

Brain Edema XII

Volume 86 of the series Acta Neurochirurgica Supplements pp 267-269

A role of glial fibrillary acidic protein in hippocampal degeneration after cerebral trauma or kainate-induced seizure

  • Naoki OtaniAffiliated withDepartment of Neurosurgery, National Defense Medical College
  • , H. NawashiroAffiliated withDepartment of Neurosurgery, National Defense Medical College
  • , N. NomuraAffiliated withDepartment of Neurosurgery, National Defense Medical College
  • , S. FukuiAffiliated withDepartment of Neurosurgery, National Defense Medical College
  • , N. TsuzukiAffiliated withDepartment of Neurosurgery, National Defense Medical College
  • , S. IshiharaAffiliated withDepartment of Neurosurgery, National Defense Medical College
  • , K. ShimaAffiliated withDepartment of Neurosurgery, National Defense Medical College

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Abstract

Astrocytes perform a variety of functions in the adult central nervous system (CNS). Recent evidence suggests the robust upregulation of glial fibrillary acidic protein (GFAP) after CNS insult. However, little is known about the role of GFAP in the hippocampal degeneration after brain injury. We herein compared the GFAP knockout (KO) and wild type (WT) mice on the histological and behavioral outcome in response to cerebral trauma or kainic acid (KA)-induced seizure. Although all KO mice showed hippocampal CA3 neuronal degeneration, WT mice did not show any neuronal degeneration in CA3 subfield at 72 hrs after trauma. Thereafter, KO mice showed a higher susceptibility to KA-induced seizures and an increased number of pyknotic CA3 neurons 72 hrs after KA administration. These results indicate that GFAP plays a crucial role in the hippocampal neurodegeneration after CNS insult.

Keywords

Astrocytes glial fibrillary acidic protein hippocampus excitotoxicity kainate seizures traumatic brain injury