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Microscale Biomaterials for Tissue Engineering

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Book cover Biomaterials for Tissue Engineering Applications

Abstract

Microscale and high throughput technologies are powerful tools for addressing many of the challenges in the field of tissue engineering. In this chapter, we present an overview of these technologies and their applications in controlling the cellular microenviroment for tissue engineering applications. We focus on concepts and techniques that can be used to create two- and three-dimensional tissue engineering substrates and scaffolds. Common to these techniques is the ability to control one or more aspects of the cellular microenvironment, including chemical and mechanical cues, cell–cell, cell–matrix, and cell-soluble factor interactions. We also discuss recent developments in high throughput techniques that are used to explore the vast number of combinations of factors that comprise the cellular microenvironment.

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Acknowledgements

This chapter was supported by the National Institutes of Health (EB007249; DE019024; HL092836), National Science Foundation (DMR0847287), the institute for Soldier Nanotechnology, and the US Army Corps of Engineers. H.K. acknowledges support from JSPS Fellowship for Research Abroad.

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Authors and Affiliations

  1. Department of Medicine, Center for Biomedical Engineering, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA

    Ali Khademhosseini

  2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139

    Ali Khademhosseini

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  1. Ian Wheeldon
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  2. Javier Fernandez
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  3. Hojae Bae
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  4. Hirokazu Kaji
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  5. Ali Khademhosseini
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Correspondence to Ali Khademhosseini .

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  1. Dept. of Bioengineering, University of Pennsylvania, 210 S. 33rd Street, 240 Skirkanich Hall, 19104-6321, Philadelphia, Pennsylvania, USA

    Jason A. Burdick

  2. Dept. of Orthopaedic Surgery McKay Orthopaedic Research Laboratory, University of Pennsylvania, 36th Street and Hamilton Walk, 19104, Philadelphia, Pennsylvania, USA

    Robert L. Mauck

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Wheeldon, I., Fernandez, J., Bae, H., Kaji, H., Khademhosseini, A. (2011). Microscale Biomaterials for Tissue Engineering. In: Burdick, J.A., Mauck, R.L. (eds) Biomaterials for Tissue Engineering Applications. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0385-2_5

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