Chapter

Lymphoid Neoplasias I

Volume 64 of the series Recent Results in Cancer Research pp 235-240

Evolution of Immunoblastic Lymphoma in Angioimmunoblastic Lymphadenopathy

  • B. N. Nathwani
  • , H. Rappaport
  • , E. M. Moran
  • , G. A. Pangalis
  • , H. Kim

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Abstract

Angioimmunoblastic lymphadenopathy (AILD) [4, 5] or immunoblastic lymphadenopathy [7] is a systemic disease clinically characterized by fever, generalized lymphadenopathy, and hepatosplenomegaly. Polyclonal hypergammaglobulinemia, and Coombs’ positive hemolytic anemia are frequently present. The lymph nodes in AILD reveal a polymorphic picture consisting of a proliferation of small vessels, immunoblasts, and plasma cells. Similar clinical and histologic observations have been reported under other designations [3,10,14].