Antithrombin Replacement in DIC and MOF

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Gram-negative septicemia is a major clinical problem, because it is difficult to combat and is associated with a mortality of >50% [1]. Endotoxin released from the bacterial cell wall induced a wide variety of pathological conditions including disseminated intravascular coagulation (DIC) and acute respiratory distress syndrome (ARDS) [2]. The occurrence of these catastrophic events in septicemia is thought to be related to the action of cytokines or other inflammatory mediators derived from activated leukocytes [2]. Among the abnormalities of organ function observed in septicemia, acute respiratory failure is particularly important because it can result in ARDS which can be a prerequisite for multiple organ failure (MOF) [3, 4].