Human Pathogenic Papillomaviruses

Volume 186 of the series Current Topics in Microbiology and Immunology pp 131-156

Molecular Pathogenesis of Cancer of the Cervix and Its Causation by Specific Human Papillomavirus Types

  • H. zur HausenAffiliated withDeutsches Krebsforschungszentrum

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Less than 10 years after publication of the hypothesis of a papillomavirus etiology of cancer of the cervix (zur Hausen 1975, 1976, 1977), the DNAs of the first cervical cancer-associated human papillomavirus (HPV) types were cloned and characterized. These DNAs are regularly and frequently found in biopsies obtained from cervical cancer patients throughout the world (Dürst et al. 1983; Boshart et al. 1984).