Current Topics in Pathology Volume 89, 1995, pp 273-296

Alveolar Rhabdomyosarcoma: A Prognostically Unfavorable Rhabdomyosarcoma Type and Its Necessary Distinction from Embryonal Rhabdomyosarcoma

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Abstract

Since publication of the classic descriptions by Riopelle and ThÉRiault (1956) and Enzinger and Shiraki (1969) the morphology of alveolar rhabdomyosarcoma (aRMS) has been well known. RMS presenting with clear and unequivocal (pseudo)alveolar spaces can be recognized at first sight as the alveolar (sub-)type of RMS. On the other hand, a diagnosis of aRMS may be difficult in cases which display neither significant evidence of rhabdomyogenesis in conventionally stained slides nor unambiguous alveolar spaces. In such cases the diagnosis of RMS must be confirmed by special staining including immunohistochemistry.