Developmental Studies on Brain Extracellular Space: Activity-Dependent K+ Accumulation and Shrinkage

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Abstract

Until recently, the microenvironment of cells within the mammalian central nervous system (CNS) has been largely neglected. Observations over the last 10 years, however, have established that the extracellular space (ECS) of brain is a very dynamic compartment with regard to its ionic contents as well as its dimensions (see for example, [16]). Our experiments focus on two aspects of ECS dynamics which are related to intense neural activity: K+ ceiling level and ECS shrinkage.