Chapter

Attempts to Understand Metastasis Formation I

Volume 213/1 of the series Current Topics in Microbiology 213/I and Immunology pp 123-161

The E-cadherin/Catenin Complex in Invasion and Metastasis

  • M. E. BrackeAffiliated withLaboratory of Experimental Cancerology, Department of Radiotheraphy, Nuclear Medicine and Experimental Cancerology, Poli 7, University Hospital
  • , F. M. Van RoyAffiliated withLaboratory of Molecular Biology, Section of Molecular Cell Biology, University of Gent
  • , M. M. MareelAffiliated withLaboratory of Experimental Cancerology, Department of Radiotheraphy, Nuclear Medicine and Experimental Cancerology, Poli 7, University Hospital

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Abstract

Cancer cells are genetically predisposed to contribute to the formation of a malignant tumor. As a population they do not respect tissue boundaries, but penetrate into the surrounding normal tissues. On their way to lymph or blood vessels they create a path of destruction. This invasive behavior eventually gives access to the circulation, and opens a gate to metastatic dissemination(Nicolson et al.; Fidler and Hart 1982; Mareel et al. 1993).