Summary
Cyanobacterial toxins are produced by terrestrial- fresh-, brackish- and sea-water cyanobacteria of cosmopolitan occurrence. These toxins present acute and chronic hazards to human and animal health and are responsible for isolated, sporadic animal fatalities (mammals, fish, birds) each year. Human health problems are associated with the ingestion of, and contact with cyanobacterial blooms and their toxins. Modes of action of cyanobacterial neurotoxins, hepatotoxins and skin irritants are considered. Recent indications of the accumulation of cyanobacterial toxins in fish, their effect on crop plants and their association with the deaths of human dialysis patients are discussed. These findings and events indicate an incomplete understanding of the exposure routes of these natural toxins and the need for greater awareness of their occurrence and properties among users of waterbodies which are prone to cyanobacterial bloom development.
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References
Abe T, Lawson T, Weyers JDB, Codd GA (1996) Microcystin-LR inhibits photosynthesis of Phaseolus vulgaris primary leaves: implication for current spray irrigation practice. New Phytologist 133: 651–658.
Baker PD, Humpage AR (1994) Toxicity associated with commonly occurring cyanobacteria in surface waters of the Murray-Darling Basin, Australia. Australian Journal of Marine and Freshwater Research 45: 773–786.
Bell SG, Codd GA (1994) Cyanobacterial toxins and human health. Reviews in Medical Microbiology 5: 256–264.
Bell SG, Codd GA (1996) Detection, analysis and risk assessment of cyanobacterial toxins. In: Hester RE, Harrison RM (eds) Agricultural Chemicals and the Environment. The Royal Society of Chemistry, Cambridge, pp 109–122.
Carmichael WW (1982) Chemical and toxicological studies of the toxic freshwater cyanobacteria Microcystis aeruginosa, Anabaena flos-aquae and Aphanizomenon flos-aquae. South African Journal of Science 78:367–372.
Carmichael WW (1992) Cyanobacteria secondary metabolites - the cyanotoxins. Journal of Applied Bacteriology 72: 445–459.
Carmichael WW, Falconer IR (1993) Diseases related to freshwater blue-green algal toxins and control measures. In: Falconer IR (ed) Algal Toxins in Seafood and Drinking Water, Academic Press, London, pp 187–209.
Codd GA (1994) Blue-green algal toxins: water-borne hazards to health. In: Golding AMB, Noah N, Stamwell-Smith, London R (eds) Water and Public Health, Smith-Gordon, London, pp 271–278.
Codd GA (1995) Cyanobacterial toxins: occurrence, properties and biological significance. Water Science and Technology 32:149–56.
Codd GA, Bell SG (1996) The Occurrence and Fate of Blue-Green Algal Toxins in Freshwater. NRA R&D Report 29, HMSO, London, pp 30.
Codd GA, Bell SG, Brooks WP (1989) Cyanobacterial toxins in water. Water Science and Technology 21:1–13.
Codd GA, Edwards C, Beattie KA, Barr WM, Gunn GJ (1992) Fatal attraction to cyanobacteria? Nature 359:110–111.
Codd GA, Jefferies TM, Keevil CW, Potter E (1994b) (eds) Detection Methods for Cyanobacterial Toxins. The Royal Society of Chemistry, Cambridge, pp 191.
Codd GA, Steffensen DA, Burch MD, Baker PD (1994a) Toxic blooms of cyanobacterial in Lake Alexandrina, South Australian - learning from history. Australian Journal of Marine and Freshwater Research 45: 731–736.
Dunn J (1996) Algae kills dialysis patients in Brazil. British Medical Journal 312: 1183–1184.
Eriksson JE, Meriluoto JAP, Lindholm T (1986) Can cyanobacterial peptide toxins accumulate in aquatic food chains? In: Megusar F, Gantar M (eds) Proceedings of the IV International Symposium on Microbial Ecology. Slavonic Society for Microbiology, Ljubljana, pp 655–658.
Falconer IR (1994) Health problems from exposure to cyanobacteria and proposed safety guidelines for drinking and recreational water. In: (see Codd et al., 1994b) pp 3–10.
Falconer IR, Choice A, Hosja W (1992) Toxicity of edible mussels (Mytilus edulis) growing naturally in an estuary during a water bloom of the blue-green alga Nodularia spumigena. Environmental Toxicology and Water Quality 7:119–124.
Fitzgeorge RB, Clark SA, Keevil CW (1994) Routes of intoxication In: (see Codd et al., 1994b) pp 69–74.
Fogg GE, Stewart WDP, Fay P, Walsby AE (1993) The Blue-Green Algae. Academic Press, New York and London, pp 459.
Hindman SH, Favero M, Carson LA, Peterson NJ, Schonberger LB, Solans JT (1975) Pyrogenic reaction during hemodialysis caused by extramural endotoxin. The Lancet 2: 731–732.
Hunter PR (1994) An epidemiological critique of reports of human illness associated with cyanobacteria. In: (see Codd et al., 1994b) pp 11–18.
MacKintosh C, Beattie KA, Klumpp S, Cohen P, Codd GA (1990) Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Letters 264:187–192.
Negri AP, Jones GJ (1995) Bioaccumulation of paralytic shellfish poisoning (PSP) toxins from the cyanobacterium Anabaena circinalis by the freshwater mussel Alathyria condola. Toxicon 33: 667–678.
NRA (1990) Toxic Blue-Green Algae. Water Quality Series No. 2. National Rivers Authority, London, pp 125.
Raziuddin S, Siegelman HW, Tornabene TG (1983) Lipopolysaccharides of the cyanobacterium Microcystis aeruginosa. European Journal of Biochemistry 137: 333–336.
Ressom R, Soong FS, Fitzgerald J, Turczynowicz L, El Saadi O, Roder D, Maynard T, Falconer IR (1994) Health Effects of Cyanobacteria (Blue-Green Algae). National Health and Medical Research Council, Canberra, pp 108.
Rinehart KL, Namikoshi M, Choi BW (1994) Structure and biosynthesis of toxins from blue-green algae (cyanobacteria). Journal of Applied Phycology 6:159–176.
Skulberg OM, Carmichael WW, Codd GA, Skulberg R (1993) Taxonomy of toxic cyanophyceae (cyanobacteria). In: Falconer IR (ed) Algal Toxins in Seafood and Drinking Water, Academic Press, London.
Steffensen DS, Nicholson BC (1994) (eds) Toxic Cyanobacteria: Current Status of Research and Management. Australian Centre for Water Quality Research, Adelaide, PP 172.
van Hoof F, van Es T, D’hout D, de Pauw N (1994) Screening of cyanobacterial toxins in Microcystis aeruginosa collected from blooms and cultures. In (see Codd et al., 1994b), pp 136–138.
Yoo RS, Carmichael WW, Hoehn RC, Hrudey SE (1995) Cyanobacterial (Blue-Green Algal) Toxins: A Resource Guide. American Water Works Association Research Foundation, Denver, pp 229.
Yu S-Z (1989) Drinking water and primary liver cancer. In: Tang ZY, Wu MC, Xia SS (eds) Primary Liver Cancer, China Academic Publishers, Beijing, pp 30–37.
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Codd, G.A., Ward, C.J., Bell, S.G. (1997). Cyanobacterial Toxins: Occurrence, Modes of Action, Health Effects and Exposure Routes. In: Seiler, J.P., Vilanova, E. (eds) Applied Toxicology: Approaches Through Basic Science. Archives of Toxicology, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60682-3_38
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DOI: https://doi.org/10.1007/978-3-642-60682-3_38
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