Interactions of TCDD with Signal Transduction and Neoplastic Development in c-myc Transgenic and TGF-alpha Transgenic Mice

  • D. Schrenk
  • M. Müller
  • G. Merlino
  • S. S. Thorgeirsson
Conference paper

DOI: 10.1007/978-3-642-60682-3_35

Part of the Archives of Toxicology book series (TOXICOLOGY, volume 19)
Cite this paper as:
Schrenk D., Müller M., Merlino G., Thorgeirsson S.S. (1997) Interactions of TCDD with Signal Transduction and Neoplastic Development in c-myc Transgenic and TGF-alpha Transgenic Mice. In: Seiler J.P., Vilanova E. (eds) Applied Toxicology: Approaches Through Basic Science. Archives of Toxicology (Supplement), vol 19. Springer, Berlin, Heidelberg

Abstract

The environmental pollutant 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) is one of the most potent tumour promoters in rodent liver (Pitot et al. 1980). TCDD enhances the expansion of preneoplastic liver foci finally leading to the development of hepatocellular carcinoma. The exact mechanism of action of TCDD as a tumour promoter, however, in particular the role of dioxin receptor-mediated signalling pathways, is unknown. Recently, it has been shown, that TCDD inhibits apoptosis of preneoplastic hepatocytes rather than enhancing their proliferation (Stinchcombe et al. 1995).

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • D. Schrenk
    • 1
  • M. Müller
    • 1
  • G. Merlino
    • 2
  • S. S. Thorgeirsson
    • 3
  1. 1.Institute of ToxicologyUniversity of TübingenTübingenGermany
  2. 2.Laboratory of Molecular BiologyNational Cancer InstituteBethesdaUSA
  3. 3.Laboratory of Molecular CarcinogenesisNational Cancer InstituteBethesdaUSA

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