CD21highIgMhigh Splenic B Cells Enriched in the Marginal Zone: Distinct Phenotypes and Functions

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Upon generation in the fetal liver and adult bone marrow, B lymphocytes are selected into a long-lived pool that participates in the immune response against exogenous antigens. Processes leading to the generation of long-lived naive B cells are still poorly understood, but it is clear that they include the selection of particular clones over others depending on receptor specificity and individual micro-environmental experiences.