The Angiopoietins: Yin and Yang in Angiogenesis
- S. DavisAffiliated withRegeneron Pharmaceuticals, Inc.
- , G. D. YancopoulosAffiliated withRegeneron Pharmaceuticals, Inc.
Embryonic vascular development involves a complex series of events during which endothelial cells differentiate, proliferate, migrate, and undergo morphological organization in the context of their surrounding tissues (Risau 1991, 1995). Vascular development is generally classified into two successive phases. The first, known as vasculogenesis, refers to the process whereby newly differentiated endothelial cells spontaneously coassemble into tubules that fuse to form a rather homogeneous primary vasculature in the embryo. Subsequent remodeling of this primary vascular network into large and small vessels brings into play a different process, termed angiogenesis. Angiogenesis in the embryo also leads to the sprouting of vessels into certain initially avascular organs, such as the brain. In the adult, angiogenesis accounts for neovascularization that accompanies the normal remodeling of the female reproductive organs during the menstrual cycle and pregnancy, in wound healing, and in various clinically significant pathological processes, such as tumor growth and diabetic retinopathy (Folkman 1995; Ferrara 1995; Hanahan and Folkman 1996).
- The Angiopoietins: Yin and Yang in Angiogenesis
- Book Title
- Vascular Growth Factors and Angiogenesis
- pp 173-185
- Print ISBN
- Online ISBN
- Series Title
- Current Topics in Microbiology and Immunology
- Series Volume
- Series ISSN
- Springer Berlin Heidelberg
- Copyright Holder
- Springer-Verlag Berlin Heidelberg
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- Editor Affiliations
- 12. Department of Medical Biochemistry and Microbiology Biomedical Center, University of Uppsala
- Author Affiliations
- 13. Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA
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