Chapter

Vascular Growth Factors and Angiogenesis

Volume 237 of the series Current Topics in Microbiology and Immunology pp 1-30

Vascular Endothelial Growth Factor: Molecular and Biological Aspects

  • N. FerraraAffiliated withDepartment of Cardiovascular Research, Genentech, Inc.

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Abstract

The development of a vascular supply is a fundamental requirement for organ development and differentiation during embryogenesis as well as for wound healing and reproductive functions in the adult (Folkman 1995). Angiogenesis is also implicated in the pathogenesis of a variety of disorders: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis and psoriasis (Folkman 1995; Garner 1994).