Abstract
Somatostatin is a hormone that regulates the function of several exocrine and endocrine glands. The peptide mediates its actions via five different receptors. These proteins are expressed in a tissue-specific manner. Somatostatin receptors are also present in neuroendocrine gastroenteropancreatic tumors. Two long-acting somatostatin analogues, octreotide and lanreotide, are recognized by the receptor subtypes 2 and 5. Excessive hormone secretion in carcinoid syndrome can be controlled by these drugs. In addition, at least a subgroup of patients with carcinoid syndromes respond with delayed tumor growth during octreotide therapy. In the future, the availability of the somatostatin receptor cDNAs will allow the development of specific and even more potent receptor analogues.
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References
Arnold R, Frank M (1995) Systemic chemotherapy for endocrine tumors of the pancreas: recent advances. In: Mignon M, Jensen RT (eds) Endocrine tumors of the pancreas. Karger, Basel, pp 431–438
Arnold R, Frank M (1996) Gastrointestinal endocrine tumors: medical management. Baillieres Clin Gastroenterol 10:737–759
Arnold R, Neuhaus C, Benning R, Schwerk WB, Trautmann ME, Joseph K, Bruns C (1993) Somatostatin analog sandostatin and inhibition of tumor growth in patients with metastatic endocrine gastroenteropancreatic tumors. World J Surg 17: 511–519
Arnold R, Trautmann ME, Creutzfeldt W, Benning R, Benning M, Neuhaus C, Jürgensen R, Stein K, Schäfer H, Bruns C, Dennler HJ (1996) Somatostatin analogue octreotide and inhibition of tumour growth in metastatic endocrine gastroenteropancreatic tumours. Gut 38: 430–438
Boden G (1989) Glucagonomas and insulinomas. Gastrenterol Clin North Am 18:831–847
Boden G, Ryan IG, Eisenschmidt BL, Shelmet JJ, Owen OE (1986) Treatment of inoperable glucagonoma with long-acting somatostatin analogue SMS 201–995. N Engl J Med 314: 1686–1689
Brazeau P, Vale W, Burgus R, Ling N, Butcher M, Rivier J, Guilleman R (1973) Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 179: 77–79
Clements D, Elias E (1985) Regression of metastatic VIPoma with somatostatin analogue SMS 201–995. Lancet 1:874–875
de Lecea L, Criado JR, Propero-Garcia O, Gautvik KM, Schweitzer P, Danielson PE, Dunlop CLM, Siggins GR, Nenrksen SJ, Sutcliffe JG (1996) A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature 381: 242–245
Fehmann HC; Arnold R (1996) Molekularbiologie, Pharmakologie uns Signal transduktion der fünf klonierten humanen Somatostatin Rezeptoren1. Z Gastroenterol 34:767–774
Frankton S, Bloom SR (1996) Glucagonomas. Baillieres Clin Gastroenterol 10:697–705
Fukusumi S, Kitada C, Takekawa S, Sakamoto M, Miyamoto M Hinuma S, KItano K, Fujino M (1997) Identification and characterization of a novel human cortistatin-like peptide. Biochem Biophys Res Commun 232: 157–163
Harris AG, Redfern JS (1995) Octreotide treatment of carcinoid syndrome: analysis of published dose-titration data. Aliment Pharmacol Ther 9: 387–394
Jais P, Terris B, Ruszniewski P, Le Romancer M, Reyl-Desmars F, Vlssuzaine C, Cadiot G, Mignon M, Lewin MJM (1997) Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours. Eur J Clin Invest 27:639–644
John M, Meyerhof W, Richter D (1996) Positive somatostatin receptor scintigraphy correlates with the presence of somatostatin receptor subtype 2. Gut 38: 33–39
Jonas S, John M, Boese-Landgraf J (1995) Somatostatin receptor subtypes in neuroendocrine tumor cell lines and tumor tissues. Langenbecks Arch Chir 380: 90–95
Kubota A, Yamada Y, Kagimoto S, Shimatsu A, Imamura M Tsuda K, Imura H, Seine S, Seino Y (1995) Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201–995 in treatment of human endocrine tumors. J Clin Invest 93: 1321–1325
Lamberts SWJ, Lely AJ, Herder WW, Hofland L (1996) Octreotide. N Engl J Med 334:246–254
Montminy MR, Goodman RH, Horovitch SJ, Habener JF (1984) Primary structure of the gene encoding rat prosomatostatin. Proc Natl Acad Sci USA 81:3337–3340
Patel Y, Srikant CB (1995) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hSSTRl-5). Endocrinology 135:2814–2817
Reardon DB, Dent P, Wood SL, Kong T, Sturgill TW (1997) Activation in vitro of somatostatin receptor subtypes 2, 3 or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected ras transformed NIH 3T3 cells: coexpression with catalytically inactive SHP-2 blocks responsiveness. Mol Endocrinol 11: 1062–1069
Reubi JC, Häcki W, Lamberts SWJ (1987) Hormone-producing gastrointestinal tumors contain a high density of somatostatin receptors. J Clin Endocrinol Metab 65: 1127–1134
Reubi JC, Schaer JC, Waser B, Mengod G (1994) Expression and localization of somatostatin receptor SSTR1, SSTR2 and SSTR3 mRNAs in primary human tumors using in situ hybridization. Cancer Res 54: 3455–3459
Ruszniewski P, Ducreux M, Chayvialle JA (1996) Treatment of carcinoid syndrome with the long-acting somatostatin analogue lanreotide: a prospective study in 39 patients. Gut 39: 279–283
Saltz L, Trochanowsky G, Buckley M, Heffernan B, Niedzwicki D, Tao Y, Kelsen D (1993) Octreotide as an anti-neoplastic agent in the treatment of functional and non-functional neuroendocrine tumours. Cancer 72: 244–248
Scarpignato C (1995) Somatostatin analogues in the management of endocrine tumors of the pancreas. In: Mignon M, Jensen RT (eds) Endocrine tumors of the pancreas. Karger, Basel, pp 385–414
Schaer JC, Waser B, Mengod G, Reubi JC (1997) Somatostatin receptor subtypes sstl, sst2, sst3, sst4, sst5 expression in human pituitary, gastroenteropancreatic and mammary tumors: comparison of MRNA analysis with receptor autoradiography. Int J Cancer 70: 530–537
Sharma K, Patel YC, Srikant CB (1996) Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3. Mol Endocrinol 10: 1688–1696
Shepherd JJ, Senator GB (1986) Regression of liver metastases in patient with gastrin-secreting tumour treated with SMS 201–995. Lancet 2: 574
Tomura H, Okajima F, Akbar M, Abdul-Majid M, Sho K, Kondo Y (1994) Transfected human somatostatin receptor type 2, SSTR2, not only inhibits adenylate cyclase but also stimulates phospholipase C and Ca2+ mobilization. Biochem Biophys Res Commun 200:986–992
Vikic-Topic S, Raisch KP, Kvols LK, Vuk-Pavlovic S (1995) Expression of somatostatin receptor subtypes in breast carcinoma, carcinoid tumors and renal cell carcinoma. J Clin Endocrinol Metab 80: 2974–2979
Wiedenmann B, Rath U, Radsch R, Becker F, Kommereil B (1988) Tumour regression of an ileal carcinoid under treatment with the somatostatin analogue SMS 201–995. Klin Wochenschr 66: 75–77
Wulbrand U, Wied M, Zofel P, Goke B, Arnold R, Fehmann HC (1998) Growth factor receptor expression in human gastroenteropancreatic neuroendocrine tumours. Eur J Clin Invest 28: 1038–1049
Yang L, Berk SC, Rohrer SP, Mosley RT, Guo L et al (1998] Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2. Proc Natl Acad Sci USA 95:10836
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Fehmann, HC., Wulbrand, U., Arnold, R. (2000). Treatment of Endocrine Gastroenteropancreatic Tumors with Somatostatin Analogues. In: Höffken, K., Kath, R. (eds) Peptides in Oncology III. Recent Results in Cancer Research, vol 153. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59587-5_2
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DOI: https://doi.org/10.1007/978-3-642-59587-5_2
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