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Transcriptional Regulators: Dynamic Drivers of Multicellular Formation, Cell Differentiation and Development

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Dictyostelids

Abstract

In this chapter, we examine what is known about the roles of individual transcription regulators in mediating development in Dictyostelium discoideum. We present a broad review of the field, covering genetic, biochemical, molecular, and bioinformatic experiments that illuminate transcriptional regulation in the context of developmental events. We highlight evidence for evolutionary conservation where it exists, and have sought to underscore the power of RNA sequencing as a tool for comparative studies and global analysis. We believe that as next generation, omics approaches are more widely applied, we may paint a more complete picture of the gene regulatory networks governing dictyostelid development, and gain insight into general evolutionary processes that shape developmental biology.

Rafael D. Rosengarten and Balaji Santhanam have contributed equally to this work.

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References

  • Abe K, Yanagisawa K (1983) A new class of rapidly developing mutants in Dictyostelium discoideum: implications for cyclic AMP metabolism and cell differentiation. Dev Biol 95:200–210

    Article  PubMed  CAS  Google Scholar 

  • Anjard C, Chang WT, Gross J et al (1998) Production and activity of spore differentiation factors (SDFs) in Dictyostelium. Development 125:4067–4075

    PubMed  CAS  Google Scholar 

  • Anjard C, Su Y, Loomis WF (2009) Steroids initiate a signaling cascade that triggers rapid sporulation in Dictyostelium. Development 136:803–812. doi:10.1242/dev.032607

    Article  PubMed  CAS  Google Scholar 

  • Araki T, Gamper M, Early A et al (1998) Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor. EMBO J 17:4018–4028. doi:10.1093/emboj/17.14.4018

    Article  PubMed  CAS  Google Scholar 

  • Araki T, Kawata T, Williams JG (2012) Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling. Proc Natl Acad Sci USA 109:E1931–E1937. doi:10.1073/pnas.1202715109

    Article  PubMed  CAS  Google Scholar 

  • Aubry L, Firtel R (1999) Integration of signaling networks that regulate Dictyostelium differentiation. Annu Rev Cell Dev Biol 15:469–517. doi:10.1146/annurev.cellbio.15.1.469

    Article  PubMed  CAS  Google Scholar 

  • Benabentos R, Hirose S, Sucgang R et al (2009) Polymorphic members of the lag gene family mediate kin discrimination in Dictyostelium. Curr Biol 19:567–572. doi:10.1016/j.cub.2009.02.037

    Article  PubMed  CAS  Google Scholar 

  • Bonner JT (1959) Evidence for the sorting out of cells in the development of the cellular slime molds. Proc Natl Acad Sci USA 45:379–384

    Article  PubMed  CAS  Google Scholar 

  • Bonner JT, Chiang A, Lee J, Suthers HB (1988) The possible role of ammonia in phototaxis of migrating slugs of Dictyostelium discoideum. Proc Natl Acad Sci USA 85:3885–3887

    Article  PubMed  CAS  Google Scholar 

  • Bonner JT, Har D, Suthers HB (1989) Ammonia and thermotaxis: Further evidence for a central role of ammonia in the directed cell mass movements of Dictyostelium discoideum. Proc Natl Acad Sci USA 86:2733–2736

    Article  PubMed  CAS  Google Scholar 

  • Brown JM, Firtel RA (2001) Functional and regulatory analysis of the Dictyostelium G-box binding factor. Dev Biol 234:521–534. doi:10.1006/dbio.2001.0276

    Article  PubMed  CAS  Google Scholar 

  • Ceccarelli A, Mahbubani H, Williams JG (1991) Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in Dictyostelium. Cell 65:983–989

    Article  PubMed  CAS  Google Scholar 

  • Ceccarelli A, Mahbubani HJ, Insall R et al (1992) A G-rich sequence element common to Dictyostelium genes which differ radically in their patterns of expression. Dev Biol 152:188–193

    Article  PubMed  CAS  Google Scholar 

  • Chang WT, Newell PC, Gross JD (1996) Identification of the cell fate gene stalky in Dictyostelium. Cell 87:471–481

    Article  PubMed  CAS  Google Scholar 

  • Chen Z, Schaap P (2012) The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium. Nature 488:680–683. doi:10.1038/nature11313

    Article  PubMed  CAS  Google Scholar 

  • Curk T, Demsar J, Xu Q et al (2005) Microarray data mining with visual programming. Bioinformatics 21:396–398. doi:10.1093/bioinformatics/bth474

    Article  PubMed  CAS  Google Scholar 

  • Dormann D, Abe T, Weijer CJ, Williams J (2001) Inducible nuclear translocation of a STAT protein in Dictyostelium prespore cells: implications for morphogenesis and cell-type regulation. Development 128:1081–1088

    PubMed  CAS  Google Scholar 

  • Dynes JL, Clark AM, Shaulsky G et al (1994) LagC is required for cell–cell interactions that are essential for cell-type differentiation in Dictyostelium. Genes Dev 8:948–958

    Article  PubMed  CAS  Google Scholar 

  • Early AE, Gaskell MJ, Traynor D, Williams JG (1993) Two distinct populations of prestalk cells within the tip of the migratory Dictyostelium slug with differing fates at culmination. Development 118:353–362

    PubMed  CAS  Google Scholar 

  • Eichinger L, Pachebat JA, Glöckner G et al (2005) The genome of the social amoeba Dictyostelium discoideum. Nature 435:43–57. doi:10.1038/nature03481

    Article  PubMed  CAS  Google Scholar 

  • Escalante R, Iranfar N, Sastre L, Loomis WF (2004) Identification of genes dependent on the MADS box transcription factor SrfA in Dictyostelium discoideum development. Eukaryot Cell 3:564–566

    Article  PubMed  CAS  Google Scholar 

  • Escalante R, Moreno N, Sastre L (2003) Dictyostelium discoideum developmentally regulated genes whose expression is dependent on MADS box transcription factor SrfA. Eukaryot Cell 2:1327–1335

    Article  PubMed  CAS  Google Scholar 

  • Escalante R, Sastre L (1998) A Serum Response Factor homolog is required for spore differentiation in Dictyostelium. Development 125:3801–3808

    PubMed  CAS  Google Scholar 

  • Escalante R, Sastre L (2002) Regulated expression of the MADS-box transcription factor SrfA mediates activation of gene expression by protein kinase A during Dictyostelium sporulation. Mech Dev 117:201–208

    Article  PubMed  CAS  Google Scholar 

  • Escalante R, Vicente JJ, Moreno N, Sastre L (2001) The MADS-box gene srfA is expressed in a complex pattern under the control of alternative promoters and is essential for different aspects of Dictyostelium development. Dev Biol 235:314–329. doi:10.1006/dbio.2001.0303

    Article  PubMed  CAS  Google Scholar 

  • Faix J, Kreppel L, Shaulsky G et al (2004) A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system. Nucleic Acids Res 32:e143. doi:10.1093/nar/gnh136

    Article  PubMed  Google Scholar 

  • Firtel RA (1996) Interacting signaling pathways controlling multicellular development in Dictyostelium. Curr Opin Genet Dev 6:545–554

    Article  PubMed  CAS  Google Scholar 

  • Fukuzawa M (2011) Control of prestalk-cell differentiation by transcription factors. Dev Growth Differ 53:538–547. doi:10.1111/j.1440-169X.2011.01269.x

    Article  PubMed  CAS  Google Scholar 

  • Fukuzawa M, Araki T, Adrian I, Williams JG (2001) Tyrosine phosphorylation-independent nuclear translocation of a Dictyostelium STAT in response to DIF signaling. Mol Cell 7:779–788

    Article  PubMed  CAS  Google Scholar 

  • Fukuzawa M, Hopper N, Williams J (1997) cudA: a Dictyostelium gene with pleiotropic effects on cellular differentiation and slug behaviour. Development 124:2719–2728

    PubMed  CAS  Google Scholar 

  • Fukuzawa M, Williams JG (2000) Analysis of the promoter of the cudA gene reveals novel mechanisms of Dictyostelium cell type differentiation. Development 127:2705–2713

    PubMed  CAS  Google Scholar 

  • Fukuzawa M, Zhukovskaya NV, Yamada Y et al (2006) Regulation of Dictyostelium prestalk-specific gene expression by a SHAQKY family MYB transcription factor. Development 133:1715–1724. doi:10.1242/dev.02327

    Article  PubMed  CAS  Google Scholar 

  • Galardi-Castilla M, Pergolizzi B, Bloomfield G et al (2008) SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium. Dev Biol 316:260–274. doi:10.1016/j.ydbio.2008.01.026

    Article  PubMed  CAS  Google Scholar 

  • Gomer RH, Yuen IS, Firtel RA (1991) A secreted 80 x 10(3) Mr protein mediates sensing of cell density and the onset of development in Dictyostelium. Development 112:269–278

    PubMed  CAS  Google Scholar 

  • Guo K, Anjard C, Harwood A et al (1999) A myb-related protein required for culmination in Dictyostelium. Development 126:2813–2822

    PubMed  CAS  Google Scholar 

  • Haberstroh L, Galindo J, Firtel RA (1991) Developmental and spatial regulation of a Dictyostelium prespore gene: cis-acting elements and a cAMP-induced, developmentally regulated DNA binding activity. Development 113:947–958

    PubMed  CAS  Google Scholar 

  • Heidel AJ, Lawal HM, Felder M et al (2011) Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication. Genome Res 21:1882–1891. doi:10.1101/gr.121137.111

    Article  PubMed  CAS  Google Scholar 

  • Hirose S, Benabentos R, Ho H-I et al (2011) Self-recognition in social amoebae is mediated by allelic pairs of tiger genes. Science 333:467–470. doi:10.1126/science.1203903

    Article  PubMed  CAS  Google Scholar 

  • Hjorth AL, Khanna NC, Firtel RA (1989) A trans-acting factor required for cAMP-induced gene expression in Dictyostelium is regulated developmentally and induced by cAMP. Genes Dev 3:747–759

    Article  PubMed  CAS  Google Scholar 

  • Hjorth AL, Pears C, Williams JG, Firtel RA (1990) A developmentally regulated trans-acting factor recognizes dissimilar G/C-rich elements controlling a class of cAMP-inducible Dictyostelium genes. Genes Dev 4:419

    Article  PubMed  CAS  Google Scholar 

  • Horn J, Dietz-Schmidt A, Zündorf I et al (1999) A Dictyostelium protein binds to distinct oligo(dA) x oligo(dT) DNA sequences in the C-module of the retrotransposable element DRE. Eur J Biochem 265:441–448

    Article  PubMed  CAS  Google Scholar 

  • Huang E, Blagg SL, Keller T et al (2006) bZIP transcription factor interactions regulate DIF responses in Dictyostelium. Development 133:449–458. doi:10.1242/dev.02240

    Article  PubMed  CAS  Google Scholar 

  • Huang E, Talukder S, Hughes TR et al (2011) BzpF is a CREB-like transcription factor that regulates spore maturation and stability in Dictyostelium. Dev Biol 358:137–146. doi:10.1016/j.ydbio.2011.07.017

    Article  PubMed  CAS  Google Scholar 

  • Iranfar N, Fuller D, Loomis WF (2006) Transcriptional regulation of post-aggregation genes in Dictyostelium by a feed-forward loop involving GBF and LagC. Dev Biol 290:460–469. doi:10.1016/j.ydbio.2005.11.035

    Article  PubMed  CAS  Google Scholar 

  • Jermyn K, Traynor D, Williams J (1996) The initiation of basal disc formation in Dictyostelium discoideum is an early event in culmination. Development 122:753–760

    PubMed  CAS  Google Scholar 

  • Kawata T (2011) STAT signaling in Dictyostelium development. Dev Growth Differ 53:548–557. doi:10.1111/j.1440-169X.2010.01243.x

    Article  PubMed  CAS  Google Scholar 

  • Kawata T, Hirano T, Ogasawara S et al (2011) Evidence for a functional link between Dd-STATa and Dd-PIAS, a Dictyostelium PIAS homologue. Dev Growth Differ 53:897–909. doi:10.1111/j.1440-169X.2011.01296.x

    Article  PubMed  CAS  Google Scholar 

  • Kawata T, Shevchenko A, Fukuzawa M et al (1997) SH2 signaling in a lower eukaryote: a STAT protein that regulates stalk cell differentiation in Dictyostelium. Cell 89:909–916

    Article  PubMed  CAS  Google Scholar 

  • Keller T, Thompson CRL (2008) Cell type specificity of a diffusible inducer is determined by a GATA family transcription factor. Development 135:1635–1645. doi:10.1242/dev.020883

    Article  PubMed  CAS  Google Scholar 

  • Kessin RH (2001) Dictyostelium: evolution, cell biology, and development of multicellularity. Cambridge University press, Cambridge

    Book  Google Scholar 

  • Konijn TM, Van de Meene JG, Chang YY et al (1969) Identification of adenosine-3′,5′-monophosphate as the bacterial attractant for myxamoebae of Dictyostelium discoideum. J Bacteriol 99:510–512

    PubMed  CAS  Google Scholar 

  • Krebs JE, Lewin B, Kilpatrick ST, Goldstein ES (2013) Lewin’s Genes XI. Jones & Bartlett Publishers, Sudbury

    Google Scholar 

  • Kuwayama H, Obara S, Morio T et al (2002) PCR-mediated generation of a gene disruption construct without the use of DNA ligase and plasmid vectors. Nucleic Acids Res 30:E2

    Article  PubMed  Google Scholar 

  • Laub MT, Loomis WF (1998) A molecular network that produces spontaneous oscillations in excitable cells of Dictyostelium. Mol Biol Cell 9:3521–3532

    Article  PubMed  CAS  Google Scholar 

  • Loomis WF, Shaulsky G (2011) Developmental changes in transcriptional profiles. Dev Growth Differ 53:567–575. doi:10.1111/j.1440-169X.2010.01241.x

    Article  PubMed  CAS  Google Scholar 

  • Loughran G, Pinter K, Newell PC, Gross JD (2000) Identification of STKA-dependent genes in Dictyostelium discoideum. Differentiation 66:71–80. doi:10.1046/j.1432-0436.2000.660202.x

    Article  PubMed  CAS  Google Scholar 

  • Mann SK, Firtel RA (1989) Two-phase regulatory pathway controls cAMP receptor-mediated expression of early genes in Dictyostelium. Proc Natl Acad Sci USA 86:1924–1928

    Article  PubMed  CAS  Google Scholar 

  • Miranda ER, Rot G, Toplak M, et al. (2012) Transcriptional profiling of Dictyostelium with RNA sequencing. In: Ludwig E and Francisco R (eds) Dictyostelium discoideum Protocols, Methods in Molecular Biology 983. Humana Press, New York. doi: 10.1007/978-1-62703-302-2_8

    Google Scholar 

  • Mohanty S, Jermyn KA, Early A et al (1999) Evidence that the Dictyostelium Dd-STATa protein is a repressor that regulates commitment to stalk cell differentiation and is also required for efficient chemotaxis. Development 126:3391–3405

    PubMed  CAS  Google Scholar 

  • Motohashi KA, Morita N, Kato A, Saito T (2012) Identification of des-methyl-DIF-1 methyltransferase in Dictyostelium purpureum. Biosci Biotechnol Biochem 76:1672–1676

    Article  PubMed  CAS  Google Scholar 

  • Mu X, Lee B, Louis JM, Kimmel AR (1998) Sequence-specific protein interaction with a transcriptional enhancer involved in the autoregulated expression of cAMP receptor 1 in Dictyostelium. Development 125:3689–3698

    PubMed  CAS  Google Scholar 

  • Mu X, Spanos SA, Shiloach J, Kimmel A (2001) CRTF is a novel transcription factor that regulates multiple stages of Dictyostelium development. Development 128:2569–2579

    PubMed  CAS  Google Scholar 

  • Nuñez-Corcuera B, Birch JL, Yamada Y, Williams JG (2012) Transcriptional repression by a bZIP protein regulates Dictyostelium prespore differentiation. PLoS ONE 7:e29895. doi:10.1371/journal.pone.0029895

    Article  PubMed  Google Scholar 

  • Núñez-Corcuera B, Serafimidis I, Arias-Palomo E et al (2008) A new protein carrying an NmrA-like domain is required for cell differentiation and development in Dictyostelium discoideum. Dev Biol 321:331–342. doi:10.1016/j.ydbio.2008.06.027

    Article  PubMed  Google Scholar 

  • Ogasawara S, Shimada N, Kawata T (2009) Role of an expansin-like molecule in Dictyostelium morphogenesis and regulation of its gene expression by the signal transducer and activator of transcription protein Dd-STATa. Dev Growth Differ 51:109–122. doi:10.1111/j.1440-169X.2009.01086.x

    Article  PubMed  CAS  Google Scholar 

  • Olive EW (1901) Dictyostelium purpureum nov. sp. Proceedings of the American Academy of Arts and Sciences 37:340

    Google Scholar 

  • Otsuka H, Van Haastert PJ (1998) A novel Myb homolog initiates Dictyostelium development by induction of adenylyl cyclase expression. Genes Dev 12:1738–1748

    Article  PubMed  CAS  Google Scholar 

  • Parikh A, Huang E, Dinh C et al (2010a) New components of the Dictyostelium PKA pathway revealed by Bayesian analysis of expression data. BMC Bioinformatics 11:163. doi:10.1186/1471-2105-11-163

    Article  PubMed  Google Scholar 

  • Parikh A, Miranda ER, Katoh-Kurasawa M et al (2010b) Conserved developmental transcriptomes in evolutionarily divergent species. Genome Biol 11:R35. doi:10.1186/gb-2010-11-3-r35

    Article  PubMed  Google Scholar 

  • Pears CJ, Williams JG (1987) Identification of a DNA sequence element required for efficient expression of a developmentally regulated and cAMP-inducible gene of Dictyostelium discoideum. EMBO J 6:195

    PubMed  CAS  Google Scholar 

  • Poff KL, Skokut M (1977) Thermotaxis by pseudoplasmodia of Dictyostelium discoideum. Proc Natl Acad Sci USA 74:2007–2010

    Article  PubMed  CAS  Google Scholar 

  • Powell-Coffman JA, Schnitzler GR, Firtel RA (1994) A GBF-binding site and a novel AT element define the minimal sequences sufficient to direct prespore-specific expression in Dictyostelium discoideum. Mol Cell Biol 14:5840–5849

    Article  PubMed  CAS  Google Scholar 

  • Raper K (1935) Dictyostelium discoideum, a new species of slime mold from decaying forest leaves. J Agri Res 50:135–147

    Google Scholar 

  • Raper K (1940) Pseudoplasmodium formation and organization in Dictyostelium discoideum. J Elisha Mitchell Sci Soci 56:241–282

    Google Scholar 

  • Rathi A, Clarke M (1992) Expression of early developmental genes in Dictyostelium discoideum is initiated during exponential growth by an autocrine-dependent mechanism. Mech Dev 36:173–182

    Article  PubMed  CAS  Google Scholar 

  • Rot G, Parikh A, Curk T et al (2009) dictyExpress: a Dictyostelium discoideum gene expression database with an explorative data analysis web-based interface. BMC Bioinfo 10:265. doi:10.1186/1471-2105-10-265

    Article  Google Scholar 

  • Saito T, Kato A, Kay RR (2008) DIF-1 induces the basal disc of the Dictyostelium fruiting body. Dev Biol 317:444–453. doi:10.1016/j.ydbio.2008.02.036

    Article  PubMed  CAS  Google Scholar 

  • Schaap P, Winckler T, Nelson M et al (2006) Molecular phylogeny and evolution of morphology in the social amoebas. Science 314:661–663. doi:10.1126/science.1130670

    Article  PubMed  CAS  Google Scholar 

  • Schindler J, Sussman M (1977) Ammonia determines the choice of morphogenetic pathways in Dictyostelium discoideum. J Mol Biol 116:161–169

    Article  PubMed  CAS  Google Scholar 

  • Schmith A, Groth M, Ratka J et al (2013) Conserved gene-regulatory function of the carboxy-terminal domain of dictyostelid C-module-binding factor. Eukaryot Cell. doi:10.1128/EC.00329-12

    PubMed  Google Scholar 

  • Schnitzler GR, Fischer WH, Firtel RA (1994) Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development in Dictyostelium. Genes Dev 8:502–514

    Article  PubMed  CAS  Google Scholar 

  • Schulkes C, Schaap P (1995) cAMP-dependent protein kinase activity is essential for preaggregative gene expression in Dictyostelium. FEBS Lett 368:381–384

    Article  PubMed  CAS  Google Scholar 

  • Senoo H, Wang H-Y, Araki T et al (2012) An orthologue of the Myelin-gene Regulatory Transcription Factor regulates Dictyostelium prestalk differentiation. Int J Dev Biol 56:325–332. doi:10.1387/ijdb.120030jw

    Article  PubMed  CAS  Google Scholar 

  • Shimada N, Maeda M, Urushihara H, Kawata T (2004) Identification of new modes of Dd-STATa regulation of gene expression in Dictyostelium by in situ hybridisation. Int J Dev Biol 48:679–682. doi:10.1387/ijdb.041862ns

    Article  PubMed  CAS  Google Scholar 

  • Siol O, Dingermann T, Winckler T (2006) The C-module DNA-binding factor mediates expression of the Dictyostelium aggregation-specific adenylyl cyclase ACA. Eukaryot Cell 5:658–664. doi:10.1128/EC.5.4.658-664.2006

    Article  PubMed  CAS  Google Scholar 

  • Smith E, Williams KL (1980) Evidence for tip control of the slug/fruit switch in slugs of Dictyostelium discoideum. J Embryol Exp Morphol 57:233–240

    PubMed  CAS  Google Scholar 

  • Sucgang R, Kuo A, Tian X et al (2011) Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum. Genome Biol 12:R20. doi:10.1186/gb-2011-12-2-r20

    Article  PubMed  CAS  Google Scholar 

  • Sukumaran S, Brown JM, Firtel RA, McNally JG (1998) lagC-null and gbf-null cells define key steps in the morphogenesis of Dictyostelium mounds. Dev Biol 200:16–26. doi:10.1006/dbio.1998.8934

    Article  PubMed  CAS  Google Scholar 

  • Thewes S, Krohn S, Schmith A et al (2012) The calcineurin dependent transcription factor TacA is involved in development and the stress response of Dictyostelium discoideum. Eur J Cell Biol 91:789–799. doi:10.1016/j.ejcb.2012.07.006

    Article  PubMed  CAS  Google Scholar 

  • Thompson CR, Kay RR (2000) Cell-fate choice in Dictyostelium: intrinsic biases modulate sensitivity to DIF signaling. Dev Biol 227:56–64. doi:10.1006/dbio.2000.9877

    Article  PubMed  CAS  Google Scholar 

  • Thompson CRL, Fu Q, Buhay C et al (2004) A bZIP/bRLZ transcription factor required for DIF signaling in Dictyostelium. Development 131:513–523. doi:10.1242/dev.00939

    Article  PubMed  CAS  Google Scholar 

  • Wang B, Kuspa A (1997) Dictyostelium development in the absence of cAMP. Science 277:251–254

    Article  PubMed  CAS  Google Scholar 

  • Wang HY, Williams JG (2010) Synergy between two transcription factors directs gene expression in Dictyostelium tip-organiser cells. Int J Dev Biol 54:1301–1307. doi:10.1387/ijdb.103141hw

    Article  PubMed  CAS  Google Scholar 

  • Weirauch MT, Cote A, Norel R et al (2013) Evaluation of methods for modeling transcription factor sequence specificity. Nat Biotechnol 31:126–134. doi:10.1038/nbt.2486

    Article  PubMed  CAS  Google Scholar 

  • Winckler T, Iranfar N, Beck P et al (2004) CbfA, the C-module DNA-binding factor, plays an essential role in the initiation of Dictyostelium discoideum development. Eukaryot Cell 3:1349–1358. doi:10.1128/EC.3.5.1349-1358.2004

    Article  PubMed  CAS  Google Scholar 

  • Yamada Y, Kay RR, Bloomfield G et al (2010) A new Dictyostelium prestalk cell sub-type. Dev Biol 339:390–397. doi:10.1016/j.ydbio.2009.12.045

    Article  PubMed  CAS  Google Scholar 

  • Yamada Y, Nuñez-Corcuera B, Williams JG (2011) DIF-1 regulates Dictyostelium basal disc differentiation by inducing the nuclear accumulation of a bZIP transcription factor. Dev Biol 354:77–86. doi:10.1016/j.ydbio.2011.03.024

    Article  PubMed  CAS  Google Scholar 

  • Zhukovskaya NV, Fukuzawa M, Yamada Y et al (2006) The Dictyostelium bZIP transcription factor DimB regulates prestalk-specific gene expression. Development 133:439–448. doi:10.1242/dev.02190

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA

    Rafael D. Rosengarten, Balaji Santhanam & Mariko Katoh-Kurasawa

  2. Graduate Program in Structural Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA

    Balaji Santhanam

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  1. Rafael D. Rosengarten
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  2. Balaji Santhanam
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  3. Mariko Katoh-Kurasawa
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Correspondence to Mariko Katoh-Kurasawa .

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Editors and Affiliations

  1. , Department of Systematic Biology, University of Uppsala, Norbyvägen 18D, Uppsala, 75236, Sweden

    Maria Romeralo

  2. , Systematic Biology, University of Uppsala, Norbyvägen 18D, Uppsala, 75236, Sweden

    Sandra Baldauf

  3. Alberto Sols CSIC-UAM, Instituto de Investigaciones Biomedicas, Arturo Duperier 4, Madrd, 28029, Spain

    Ricardo Escalante

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D. Rosengarten, R., Santhanam, B., Katoh-Kurasawa, M. (2013). Transcriptional Regulators: Dynamic Drivers of Multicellular Formation, Cell Differentiation and Development. In: Romeralo, M., Baldauf, S., Escalante, R. (eds) Dictyostelids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38487-5_5

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