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Virtual Cerebellar Lesions Influence Verbal Working Memory a tDCS Study

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Converging Clinical and Engineering Research on Neurorehabilitation

Part of the book series: Biosystems & Biorobotics ((BIOSYSROB,volume 1))

Abstract

Several studies suggest that the cerebellum is involved in cognitive functions. Findings in cerebellar patient studies are inconsistent due to small group sizes and different location of lesions. Here we used cathodal transcranial direct current stimulation (tDCS) over the right cerebellum to induce non-invasive virtual cerebellar lesions in healthy participants. Before and after tDCS application participants were tested on their verbal working memory capacities by means of forward and backward digit spans. In line with lower digit spans in patients with cerebellar lesions, cerebellar tDCS reduced forward digit spans and blocked a practice dependent increase in backward digit spans. No effects of tDCS on word reading, finger tapping or the visually cued sensorimotor task were found. These results indicate a causal role of the cerebellum in verbal working memory.

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References

  1. Stoodley, C.J., Schmahmann, J.D.: Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. NeuroImage 44(2), 489–501 (2009)

    Article  Google Scholar 

  2. Baddeley, A.: Working memory: looking back and looking forward. Nature Reviews 4(10), 829–839 (2003)

    Article  Google Scholar 

  3. Paulesu, E., Frith, C.D., Frackowiak, R.S.: The neural correlates of the verbal component of working memory. Nature 362(6418), 342–345 (1993)

    Article  Google Scholar 

  4. Desmond, J.E., Gabrieli, J.D., Wagner, A.D., Ginier, B.L., Glover, G.H.: Lobular patterns of cerebellar activation in verbal working-memory and finger-tapping tasks as revealed by functional MRI. J. Neurosci. 17(24), 9675–9685 (1997)

    Google Scholar 

  5. Fiez, J.A., Petersen, S.E., Cheney, M.K., Raichle, M.E.: Impaired non-motor learning and error detection associated with cerebellar damage. A single case study. Brain 115(Pt. 1), 155–178 (1992)

    Article  Google Scholar 

  6. Timmann, D., Daum, I.: How consistent are cognitive impairments in patients with cerebellar disorders? Behavioural Neurology 23(1-2), 81–100 (2010)

    Article  Google Scholar 

  7. Schmahmann, J.D., Sherman, J.C.: The cerebellar cognitive affective syndrome. Brain 121(Pt. 4), 561–579 (1998)

    Article  Google Scholar 

  8. Galea, J.M., Jayaram, G., Ajagbe, L., Celnik, P.: Modulation of cerebellar excitability by polarity-specific noninvasive direct current stimulation. J. Neurosci. 29(28), 9115–9122 (2009)

    Article  Google Scholar 

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Correspondence to Katja Macher .

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Macher, K., Böhringer, A., Dukart, J., Villringer, A., Pleger, B. (2013). Virtual Cerebellar Lesions Influence Verbal Working Memory a tDCS Study. In: Pons, J., Torricelli, D., Pajaro, M. (eds) Converging Clinical and Engineering Research on Neurorehabilitation. Biosystems & Biorobotics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34546-3_85

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  • DOI: https://doi.org/10.1007/978-3-642-34546-3_85

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-34545-6

  • Online ISBN: 978-3-642-34546-3

  • eBook Packages: EngineeringEngineering (R0)

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