Chapter

Antibiotic Resistance

Volume 211 of the series Handbook of Experimental Pharmacology pp 167-183

Date:

Antibiotics in Phase II and III Clinical Trials

  • Anthony R. M. CoatesAffiliated withMedical Microbiology, Division of Clinical Sciences, Centre for Infection, St George’s University of London Email author 
  • , Gerry HallsAffiliated withMedical Marketing Services

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Abstract

There are 19 compounds in late-stage clinical trials, of which ten may be suitable for Gram-positive infections. However, there are only five compounds in development for Gram-negative infections, in addition to four broad-spectrum ones. There are two new classes in late-stage clinical development. This chapter discusses in some detail each of the antibiotics in Phase II and Phase III clinical trials. Only those that appear in the literature are covered. The shortage of compounds in development for Gram-negatives and the small number of new classes in the pipeline is of serious concern; this matter needs to be addressed by governments, the regulatory authorities, the pharmaceutical industry and academia urgently.

Keywords

Antibiotics Phase II Phase III clinical trials Gram-positives Gram-negatives classes combinations resistance regulation pipeline