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Advances in Automation and Robotics, Vol. 2

Volume 123 of the series Lecture Notes in Electrical Engineering pp 557-566

Modeling and Simulation for Dynamics of Anti-HBV Infection Therapy

  • Xiao ChenAffiliated withAutomation School, University of Science and Technology Beijing
  • , Lequan MinAffiliated withAutomation School, University of Science and Technology BeijingMathematics and Physics School, University of Science and Technology Beijing
  • , Yongan YeAffiliated withTraditional Chinese Internal Medicine Key Laboratory of China Education Ministry, Dongzhimen Hospital, Beijing University of Chinese Medicine
  • , Yu ZhengAffiliated withAutomation School, University of Science and Technology Beijing

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Abstract

Based on our previous researches, this paper introduces a new differential equation model to describe the dynamics of traditional Chinese medicines (TCM) + nucleoside analogues (NA) anti-HBV infection treatment for the chronic hepatitis B (CHB) patients. This model has five state variables. A treatment-activated specific term in this model is in charge of directly clearing patients’ HBV rather than damaging patients’ hepatocytes. As an application, we use this model to simulate the dynamics of TCM + NA anti-HBV infection personalized combination treatments. The numerical simulations and analysis show that the TCM + NA combination treatments are able to activate patients’ abilities of cytokine-midiated noncytolytic HBV clearance.

Keywords

Chronic HBV infection Mathematical modeling Basic virus reproductive number Global stability Numerical simulation