The transportation of dangerous goods is increasing greatly with the development of economy; the risks of it, to our human being’s safety and health, are expanding, the consequence is very serious once the accident arises. So the problems that how to choose an optimal path for it to ensure transport safety and arrive at their destinations quickly need to solve urgently. The essay takes the special nature of dangerous goods into account, builds and optimizes a model, ultimately selects a transportation route of lower risk and cost.