Chapter

Heparin - A Century of Progress

Volume 207 of the series Handbook of Experimental Pharmacology pp 307-324

Date:

Glycosaminoglycan and Chemokine/Growth Factor Interactions

  • Janis ShuteAffiliated withInstitute of Biomedical and Biomolecular Sciences, University of Portsmouth Email author 

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Abstract

Heparin and glycosaminoglycans (GAGs) related structurally to heparin, notably heparan sulphate, bind to most, if not all, chemokines and many growth factors. The chemokine and growth factor interactions with GAGs localise the peptide mediators to specific sites in tissues and influence their stability and function. This chapter discusses the nature of these interactions and the effect on the function of a number of chemokines (PF-4, interleukin-8, RANTES and SDF-1) and growth factors (FGF, HGF, VEGF) in normal physiology and the disease setting. Novel therapeutic interventions that target chemokine and growth factor interactions with GAGs are also discussed.

Keywords

Chemokine Glycosaminoglycan Growth factor Therapeutic intervention