Modern Mathematical Tools and Techniques in Capturing Complexity

Part of the series Understanding Complex Systems pp 485-494

Multiple Comparison of Change Trends in Cancer Mortality/Incidence Rates Taking with Overlapping Regions and Time-Periods

  • Nirian MartínAffiliated withDept. Statistics, Carlos III University of Madrid
  • , Yi LiAffiliated withDept. Biostatistics, Harvard School of Public HealthDep. Biostatistics & Computational Biology, Dana Farber Cancer Institute

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When analyzing trends in cancer rates, it is common to rely on the so-called Annual Percent Change (APC). For dealing with such a measure of trend, directly age-adjusted rates are usually considered. Classical methods such as pooled t-tests are often applied for comparing APCs of two groups of individuals in a simple way under independence assumption. In practice, it is quite common to find groups of interest for which the independence assumption fails because their regions or periods of time overlap. No one of the papers that deal this problem consider the case where more than two APCs are compared. In this work we propose a Wald-type test-statistic which is not difficult to compute once we provide the estimators of two or more APCs to be compared. These estimators are the minimum power divergence estimators that cover as special case those obtained by maximum likelihood.