Chapter

6th World Congress of Biomechanics (WCB 2010). August 1-6, 2010 Singapore

Volume 31 of the series IFMBE Proceedings pp 1507-1510

Curvedness Study on Atherosclerosis Plaques and Its Implications to Plaque Stress

  • H. GaoAffiliated withBrunel Institute for Bioengineering, Brunel University
  • , Q. LongAffiliated withBrunel Institute for Bioengineering, Brunel University
  • , M. GravesAffiliated withDepartment of Radiology, Addenbrooke’s Hospital
  • , Z. Y. LiAffiliated withDepartment of Radiology, Addenbrooke’s Hospital
  • , J. H. GillardAffiliated withDepartment of Radiology, Addenbrooke’s Hospital

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Abstract

Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.

Keywords

Atherosclerosis plaque stress analysis curvedness geometry features plaque vulnerability