Abstract
As one of the most important sensations, pain sensation has been studied extensively for a long time over a range of scales, from molecular level to the entire human neural system level. Thermal stimulation, as one of the three main stimulations for pain (thermal, mechanical and chemical stimuli), has been widely used in the pain study[1], such as the examination of tissue injury and sensitisation mechanisms, and the quantification of therapeutic effects of pharmacological, physical, and psychological interventions[2],[3]. However, the understanding of the underlying mechanisms of thermal pain is still far from clear, the main reason being that pain is influenced by many factors, including both physiological factors and psychological factors.
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Xu, F., Lu, T. (2011). Skin Thermal Pain Modeling. In: Introduction to Skin Biothermomechanics and Thermal Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13202-5_13
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