Magnetic Detection of the Sentinel Lymph Node in Ex Vivo Tissue with Colorectal Cancer

  • B. ten Haken
  • M. Visscher
  • J. J. Pouw
  • J. M. Klaase
  • Q. A. Pankhurst
  • J. Galindo-Millan
  • A. H. Velders
  • H. Rogalla
Conference paper

DOI: 10.1007/978-3-642-12197-5_107

Volume 28 of the book series IFMBE Proceedings (IFMBE)
Cite this paper as:
ten Haken B. et al. (2010) Magnetic Detection of the Sentinel Lymph Node in Ex Vivo Tissue with Colorectal Cancer. In: Supek S., Sušac A. (eds) 17th International Conference on Biomagnetism Advances in Biomagnetism – Biomag2010. IFMBE Proceedings, vol 28. Springer, Berlin, Heidelberg

Abstract

A new method for sentinel lymph node detection was investigated by ex-vivo experiments in colorectal cancer. A dispersion of superparamagnetic iron oxide (SPIO) nanoparticles was injected in the resected tissue around the tumor. A magnetic probe with a 2nd order gradiometer configuration was used to localize the sentinel lymph node with accumulated SPIO nanoparticles. Additional analysis of SPIO content was performed on the resected lymph nodes. High-field MRI and conventional microscopy revealed the presence and distribution of SPIO inside the lymph nodes. Magnetometry confirmed SPIO content in lymph nodes and could give an estimate of the amount of SPIO uptake.

Keywords

sentinel lymph node superparamagnetic iron oxides magnetometry MRI 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • B. ten Haken
    • 1
  • M. Visscher
    • 1
  • J. J. Pouw
    • 2
  • J. M. Klaase
    • 2
  • Q. A. Pankhurst
    • 3
  • J. Galindo-Millan
    • 4
  • A. H. Velders
    • 4
  • H. Rogalla
    • 1
  1. 1.MIRA Institute for biomedical technology and technical medicine, Department of Low Temperatures, BiomagnetismUniversity of TwenteEnschedeThe Netherlands
  2. 2.Department of SurgeryMedisch Spectrum TwenteEnschedeThe Netherlands
  3. 3.Davy-Faraday Research LaboratoryThe Royal Institution of Great BritainLondonUK
  4. 4.Department of Supramolecular Chemistry and TechnologyUniversity of Twente, MESA+ Institute for nanotechnologyEnschedeThe Netherlands