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Fungal Biotransformations in Pharmaceutical Sciences

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Book cover Industrial Applications

Part of the book series: The Mycota ((MYCOTA,volume 10))

Abstract

The regio- and stereoselective conversion of complex substrates represents one of the major advantage of microbial biotransformation. This chapter covers the biocatalytic capacities of fungi to derivatize bioactive small molecules, both from natural sources and from synthetic compounds. We focus particularly on sterol and taxane biotransformation. We also present examples at the interface of biotransformation and pathway engineering using recombinant organisms, with an emphasis on the production of lovastatin derivatives. Finally, we highlight selected studies on fungal xenometabolism which serves as a model to study the breakdown of drugs in mammals.

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Authors and Affiliations

  1. Institute for Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry, Albert-Ludwigs-Universität, Albertstrasse 25, 79104, Freiburg, Germany

    Wolfgang Hüttel

  2. Department Pharmaceutical Biology at the Hans-Knöll-Institut, Friedrich-Schiller-Universität Jena, Beutenbergstrasse 11a, 07745, Jena, Germany

    Dirk Hoffmeister

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  1. Wolfgang Hüttel
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Correspondence to Dirk Hoffmeister .

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  1. , Department of Biotechnology, International Graduate School of Zittau, Markt 23, Zittau, 02763, Sachsen, Germany

    Martin Hofrichter

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Hüttel, W., Hoffmeister, D. (2011). Fungal Biotransformations in Pharmaceutical Sciences. In: Hofrichter, M. (eds) Industrial Applications. The Mycota, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11458-8_14

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