Chapter

World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany

Volume 25/1 of the series IFMBE Proceedings pp 377-380

4D calculation and biological dosimetry of the RBE-weighted dose for scanned carbon ion beam therapy

  • A. GemmelAffiliated withGSI Helmholtz Center for Heavy Ion Research GmbH/Biophysics
  • , C. BertAffiliated withGSI Helmholtz Center for Heavy Ion Research GmbH/Biophysics
  • , N. SaitoAffiliated withGSI Helmholtz Center for Heavy Ion Research GmbH/Biophysics
  • , N. ChaudhriAffiliated withGSI Helmholtz Center for Heavy Ion Research GmbH/Biophysics
  • , G. IancuAffiliated withGSI Helmholtz Center for Heavy Ion Research GmbH/Biophysics
  • , C. v. NeubeckAffiliated withGSI Helmholtz Center for Heavy Ion Research GmbH/Biophysics
  • , M. DuranteAffiliated withGSI Helmholtz Center for Heavy Ion Research GmbH/Biophysics
  • , E. RietzelAffiliated withGSI Helmholtz Center for Heavy Ion Research GmbH/BiophysicsSiemens Healthcare, Workflow & Solutions, Particle Therapy

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Abstract

The software treatment planning for particles (TRiP) was extended by the functionality to calculate the clinically relevant RBE-weighted dose for scanned ion beams in the presence of motion. Calculations are based on 4D-CT and deformable registration. The underlying biological model is the local effect model. To validate the dose calculation algorithm experimentally a dedicated motion phantom for biological dosimetry was developed. In-vitro cell survival measurements were performed with a target dose of 9 Gy (RBE). The mean dose difference between the calculation and the measurement and its standard deviation was obtained to be 155±400 mGy (RBE). This validates the calculation within the measurement error of 519 mGy (RBE).

Keywords

scanned ion therapy 4D dose calculation target motion biological dosimetry