A Simple DNA Gate Motif for Synthesizing Large-Scale Circuits
- Cite this paper as:
- Qian L., Winfree E. (2009) A Simple DNA Gate Motif for Synthesizing Large-Scale Circuits. In: Goel A., Simmel F.C., Sosík P. (eds) DNA Computing. DNA 2008. Lecture Notes in Computer Science, vol 5347. Springer, Berlin, Heidelberg
The prospects of programming molecular systems to perform complex autonomous tasks has motivated research into the design of synthetic biochemical circuits. Of particular interest to us are cell-free nucleic acid systems that exploit non-covalent hybridization and strand displacement reactions to create cascades that implement digital and analog circuits. To date, circuits involving at most tens of gates have been demonstrated experimentally. Here, we propose a DNA catalytic gate architecture that appears suitable for practical synthesis of large-scale circuits involving possibly thousands of gates.
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