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Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields

Part of the series Biological and Medical Physics, Biomedical Engineering pp 419-437

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Raman Spectroscopy: A Tool for Tissue Engineering

  • Gavin JellAffiliated withDepartment of Materials and Institute of Biomedical Engineering, Imperial College Email author 
  • , Robin SwainAffiliated withDepartment of Materials and Institute of Biomedical Engineering, Imperial College
  • , Molly M. StevensAffiliated withDepartment of Materials and Institute of Biomedical Engineering, Imperial College

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Abstract

Raman spectroscopy can offer a non-invasive, information-rich biochemical “snapshot” of living human cells, tissues or material-cell tissue constructs rapidly(seconds–minutes), without the need of labels or contrast enhancers. This chapter details the exciting potential and challenges associated with the use of Raman spectroscopy in tissue engineering (TE). The use of Raman spectroscopy in three interlinked areas of TE will be considered: (1) the characterisation of the various scaffolds and “smart” materials, (2) the biochemical analysis of cellular behaviour important in TE (e.g. differentiation) and (3) the use of Raman spectroscopy for the analysis of tissue/extracellular matrix (ECM) formation in vitro or possibly in vivo.