Chapter

Fertility Control

Volume 198 of the series Handbook of Experimental Pharmacology pp 67-78

Date:

Proteomics of Embryonic Implantation

  • T. Garrido-Gómez
  • , F. Dominguez
  • , C. SimónAffiliated withFundación Instituto Valenciano de Infertilidad (FIVI), Instituto Universitario (IUIVI), Valencia University Email author 

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Abstract

Implantation is a complex process involving an intricate cascade of molecular interactions between the implanting blastocyst and the receptive endometrium. The molecular basis of endometrial receptivity and the mechanisms by which the blastocyst first adheres to the luminal epithelium and then penetrates into the stroma are only just beginning to be resolved. Advances in “omics” technologies, particularly proteomics and metabolomics, are set to have a major impact on the development of this field. In the wake of this information, novel targets for contraceptive intervention may become apparent.

Keywords

Embryo implantation Proteomics Secretomics