Skip to main content
SpringerLink
Log in

Biological Applications of FM-AFM in Liquid Environment

  • Chapter
  • First Online:
Book cover Noncontact Atomic Force Microscopy

Part of the book series: NanoScience and Technology ((NANO))

Abstract

Atomic force microscopy (AFM) was noted for its potential to study biological materials shortly after its first development in 1986 due to its ability to image insulators in liquid environments. The subsequent application of AFM to biology has included lateral characterization via imaging, unraveling of molecules under a tensile load and application of a force either to measure mechanical properties under the tip or to instigate a biochemical response in living cells. To date, the application of frequency modulation AFM (FM-AFM) specifically to biological materials has been limited to relatively few research groups when compared to the extensive application of AFM to biological materials. This is probably due to the perceived complexity of the technique both by researchers in the life sciences and those manufacturing liquid AFMs for biological research. In this chapter, we aim to highlight the advantages of applying the technique to biological materials.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. F.J. Giessibl, Phys. Rev. B 56, 16010 (1997)

    Article  CAS  Google Scholar 

  2. T.R. Albrecht, P. Grütter, D. Horne, D. Ruger, J. Appl. Phys. 69, 668 (1991)

    Article  Google Scholar 

  3. U. Dürig, Appl. Phys. Lett. 75, 433 (1999)

    Article  Google Scholar 

  4. J. Sader, S.P. Jarvis, Appl. Phys. Lett. 84, 1801 (2004)

    Article  CAS  Google Scholar 

  5. T. Uchihashi et al., Appl. Phys. Lett. 85, 3575 (2004)

    Article  CAS  Google Scholar 

  6. J.E. Sader, S.P. Jarvis, Phys. Rev. B 74, 195424 (2006)

    Article  CAS  Google Scholar 

  7. G.B. Kaggwa, J.I. Kilpatrick, J.E. Sader, S.P. Jarvis, Appl. Phys. Lett. 93, 011909 (2008)

    Article  CAS  Google Scholar 

  8. S.P. Jarvis, A. Oral, T.P. Weihs, J.B. Pethica, Rev. Sci. Instrum. 64, 3515 (1993)

    Article  CAS  Google Scholar 

  9. A. Buguin, O.D. Roure, P. Silberzan, Appl. Phys. Lett. 78, 2982 (2001)

    Article  CAS  Google Scholar 

  10. M.J. Higgins, C.K. Riener, T. Uchihashi, J.E. Sader, Nanotechnology 16, S85 (2005)

    Article  CAS  Google Scholar 

  11. A.D.L. Humphris, J. Tamayo, M.J. Miles, Langmuir 16, 7891 (2000)

    Article  CAS  Google Scholar 

  12. A.D.L. Humphris, M. Antognozzi, T.J. McMaster, M.J. Miles, Langmuir 18, 1729 (2002)

    Article  CAS  Google Scholar 

  13. M. Higgins, J.E. Sader, S.P. Jarvis, Biophys. J. 90, 640 (2006)

    Article  CAS  Google Scholar 

  14. J. Tamayo, A.D.L. Humphris, R.J. Owen, M.J. Miles, Biophys. J. 81, 526 (2001)

    Article  CAS  Google Scholar 

  15. S.P. Jarvis et al., J. Phys. Chem. B 104, 6091 (2000)

    Article  CAS  Google Scholar 

  16. H. Sekiguchi et al., Appl. Surf. Sci. 210, 61 (2003)

    Article  CAS  Google Scholar 

  17. C.-W. Yang et al., Nanotechnology 18, 084009 (2007)

    Article  CAS  Google Scholar 

  18. D. Ebling, H. Hölscher, B. Anczykowski, Appl. Phys. Lett. 89, 203511 (2006)

    Article  CAS  Google Scholar 

  19. B.W. Hoogenboom et al., Appl. Phys. Lett. 88, 193109 (2006)

    Article  CAS  Google Scholar 

  20. B.W. Hoogenboom, K. Suda, A. Engel, D. Fotiadis, 370, 246 (2007)

    CAS  Google Scholar 

  21. M. Higgins et al., Biophys. J. 91, 2532 (2006)

    Article  CAS  Google Scholar 

  22. F.J. Giessibl, Science 267, 68 (1995)

    Article  CAS  Google Scholar 

  23. S. Kitamura, M. Iwatsuki, Jpn. J. Appl. Phys. Part II 34, L145 (1995)

    Article  CAS  Google Scholar 

  24. T. Fukuma et al., Rev. Sci. Instrum. 76, 053704 (2005)

    Article  CAS  Google Scholar 

  25. T. Fukuma, K. Kobayashi, K. Matsushige, H. Yamada, Appl. Phys. Lett. 87, 034101 (2005)

    Article  CAS  Google Scholar 

  26. T. Fukuma et al., Appl. Phys. Lett. 86, 034103 (2005)

    Article  CAS  Google Scholar 

  27. S. Morita, R. Wiesendanger, E. Meyer (Eds.), Noncontact Atomic Force Microscopy (Nanoscience and Technology) (Springer, Berlin, 2002)

    Google Scholar 

  28. F.J. Giessibl, H. Bielefeldt, S. Hembacher, J. Mannhart, Appl. Surf. Sci. 140, 352 (1999)

    Article  CAS  Google Scholar 

  29. T. Fukuma, S.P. Jarvis, Rev. Sci. Instrum. 77, 043701 (2006)

    Article  CAS  Google Scholar 

  30. T. Fukuma, M.J. Higgins, S.P. Jarvis, Biophys. J. 92, 3603 (2007)

    Article  CAS  Google Scholar 

  31. T. Fukuma, M.J. Higgins, S.P. Jarvis, Phys. Rev. Lett. 98, 106101 (2007)

    Article  CAS  Google Scholar 

  32. T. Fukuma, A.S. Mostaert, S.P. Jarvis, Nanotechnology 19, 384010 (2008)

    Article  CAS  Google Scholar 

  33. T. Fukuma, J.I. Kilpatrick, S.P. Jarvis, Rev. Sci. Instrum. 77, 123703 (2006)

    Article  CAS  Google Scholar 

  34. F. Ohnesorge, G. Binnig, Science 260, 1451 (1993)

    Article  CAS  Google Scholar 

  35. F.J. Giessibl, S. Hembacher, H. Bielefeldt, J. Mannhart, Science 289, 422 (2000)

    Article  CAS  Google Scholar 

  36. M. Rappolt, G. Pabst, H. Amenitsch, P. Laggner, Coll. Surf. A 183–185, 171 (2001)

    Article  Google Scholar 

  37. M. Ross, C. Steinen, H.-J. Galla, A. Janshoff, Langmuir 17, 2437 (2001)

    Article  CAS  Google Scholar 

  38. J.T. Groves, S.G. Boxer, H.M. McConnell, J. Phys. Chem. B 104, 11409 (2000)

    Article  CAS  Google Scholar 

  39. S. Ohki, N. Düzgüneş, K. Leonards, Biochemistry 21, 2127 (1982)

    Article  CAS  Google Scholar 

  40. S. Ohki, K. Arnold, Coll. Surf. B 18, 83 (2000)

    Article  CAS  Google Scholar 

  41. L. Herbette, C.A. Napolitano, R.V. McDaniel, Biophys. J. 46, 677 (1984)

    Article  CAS  Google Scholar 

  42. C. Altenbach, J. Seelig, Biochemistry 23, 3913 (1984)

    Article  CAS  Google Scholar 

  43. T.R. Hermann, A.R. Jayaweera, A.E. Shamoo, Biochemistry 25, 5834 (1986)

    Article  Google Scholar 

  44. H. Binder, O. Zschörnig, Chem. Phys. Lipids 115, 39 (2002)

    Article  CAS  Google Scholar 

  45. M.L. Berkowitz, D.L. Bostick, S. Pandit, Chem. Rev. 106, 1527 (2006)

    Article  CAS  Google Scholar 

  46. S. Garcia-Manyes, G. Oncins, F. Sanz, Biophys. J. 89, 1812 (2005)

    Article  CAS  Google Scholar 

  47. R.A. Böckmann, A. Hac, T. Heimburg, H. Grubmüller, Biophys. J. 85, 1647 (2003)

    Article  Google Scholar 

  48. P. Westermark et al., Amyloid 12, 1 (2005)

    Article  CAS  Google Scholar 

  49. P. Westermark, FEBS J. 272, 5942 (2005)

    Article  CAS  Google Scholar 

  50. P. Westermark, C. Wernstedt, E. Wilander, D.W. Hayden, Proc. Natl. Acad. Sci. USA 84, 3881 (1987)

    Article  CAS  Google Scholar 

  51. O.S. Makin, L.C. Serpell 335, 1279 (2004)

    Google Scholar 

  52. H. Hölscher, S.M. Langkat, A. Schwarz, R. Wiesendanger, Appl. Phys. Lett. 81, 4428 (2002)

    Article  CAS  Google Scholar 

  53. M. Abe et al., Appl. Phys. Lett. 90, 203103 (2007)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Frontier Science Organization, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan

    Takeshi Fukuma & Suzanne P. Jarvis

Authors
  1. Takeshi Fukuma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Suzanne P. Jarvis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takeshi Fukuma .

Editor information

Editors and Affiliations

  1. Graduate School of Engineering, Dept. of Electrical, Electronic and, Osaka University, Yamada-Oka 2-1, Suita, 565-0871, Japan

    Seizo Morita

  2. Institut für Experimentelle und, Angewandte Physik, Universität Regensburg, Universitätsstr. 31, Regensburg, 93053, Germany

    Franz J. Giessibl

  3. FB Physik, Inst. Angewandte Physik, Universität Hamburg, Jungiusstr. 11, Hamburg, 20355, Germany

    Roland Wiesendanger

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Fukuma, T., Jarvis, S.P. (2009). Biological Applications of FM-AFM in Liquid Environment. In: Morita, S., Giessibl, F., Wiesendanger, R. (eds) Noncontact Atomic Force Microscopy. NanoScience and Technology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01495-6_16

Download citation

Publish with us

Policies and ethics

Search

Navigation