Genotype and Haplotype Reconstruction from Low-Coverage Short Sequencing Reads

  • Ion Măndoiu
Conference paper

DOI: 10.1007/978-3-642-00727-9_7

Volume 5462 of the book series Lecture Notes in Computer Science (LNCS)
Cite this paper as:
Măndoiu I. (2009) Genotype and Haplotype Reconstruction from Low-Coverage Short Sequencing Reads. In: Rajasekaran S. (eds) Bioinformatics and Computational Biology. Lecture Notes in Computer Science, vol 5462. Springer, Berlin, Heidelberg

Abstract

Recent advances in high-throughput sequencing (HTS) technologies have led to orders of magnitude higher throughput compared to classic Sanger sequencing (see [3] for a review). Coupled with continuously decreasing sequencing costs, HTS data provides opportunities to study genome structure, function, and evolution at an unprecedented scale, and is profoundly transforming biomedical research.

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Ion Măndoiu
    • 1
  1. 1.Department of Computer Science & EngineeringUniversity of ConnecticutStorrsUSA