Genotype and Haplotype Reconstruction from Low-Coverage Short Sequencing Reads
- Cite this paper as:
- Măndoiu I. (2009) Genotype and Haplotype Reconstruction from Low-Coverage Short Sequencing Reads. In: Rajasekaran S. (eds) Bioinformatics and Computational Biology. Lecture Notes in Computer Science, vol 5462. Springer, Berlin, Heidelberg
Recent advances in high-throughput sequencing (HTS) technologies have led to orders of magnitude higher throughput compared to classic Sanger sequencing (see  for a review). Coupled with continuously decreasing sequencing costs, HTS data provides opportunities to study genome structure, function, and evolution at an unprecedented scale, and is profoundly transforming biomedical research.