Local Identification of Piecewise Deterministic Models of Genetic Networks

  • Eugenio Cinquemani
  • Andreas Milias-Argeitis
  • Sean Summers
  • John Lygeros
Conference paper

DOI: 10.1007/978-3-642-00602-9_8

Part of the Lecture Notes in Computer Science book series (LNCS, volume 5469)
Cite this paper as:
Cinquemani E., Milias-Argeitis A., Summers S., Lygeros J. (2009) Local Identification of Piecewise Deterministic Models of Genetic Networks. In: Majumdar R., Tabuada P. (eds) Hybrid Systems: Computation and Control. HSCC 2009. Lecture Notes in Computer Science, vol 5469. Springer, Berlin, Heidelberg

Abstract

We address the identification of genetic networks under stationary conditions. A stochastic hybrid description of the genetic interactions is considered and an approximation of it in stationary conditions is derived. Contrary to traditional structure identification methods based on fitting deterministic models to several perturbed equilibria of the system, we set up an identification strategy which exploits randomness as an inherent perturbation of the system. Estimation of the dynamics of the system from sampled data under stability constraints is then formulated as a convex optimization problem. Numerical results are shown on an artificial genetic network model. While our methods are conceived for the identification of interaction networks, they can as well be applied in the study of general piecewise deterministic systems with randomly switching inputs.

Keywords

Piecewise deterministic systems state-space identification Markov processes sampled systems convex optimization 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Eugenio Cinquemani
    • 1
  • Andreas Milias-Argeitis
    • 1
  • Sean Summers
    • 1
  • John Lygeros
    • 1
  1. 1.Institut für Automatik, ETH ZurichSwitzerland

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