The Mycota Volume 15, 2009, pp 331-351
Date: 20 Jul 2009

Biosynthesis of Fungal Polyketides

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Fungal polyketides comprise a diverse group of secondary metabolites that play an important role for drug discovery, as pigments, and as mycotoxins. Their biosynthesis is governed by multidomain enzymes, so-called fungal type I polyketide synthases (PKS). Investigating the molecular basis of polyketide biosynthesis in fungi is of great importance for ecological and pharmacological reasons. Cloning, functional analysis and expression of fungal PKS genes also set the basis for engineering a yet largely untapped biosynthetic potential. This review summarizes the current knowledge on fungal PKS.