Chapter

13th International Conference on Biomedical Engineering

Volume 23 of the series IFMBE Proceedings pp 774-777

Microdevice for Trapping Circulating Tumor Cells for Cancer Diagnostics

  • S. J. TanAffiliated withA*STAR, Institute of MicroelectronicsNUS Graduate School for Integrative Sciences and Engineering, National University of Singapore
  • , L. YobasAffiliated withA*STAR, Institute of Microelectronics
  • , G. Y. H. LeeAffiliated withSingapore-MIT Alliance
  • , C. N. OngAffiliated withLife Sciences Institute, National University of Singapore
  • , C. T. LimAffiliated withA*STAR, Institute of MicroelectronicsNUS Graduate School for Integrative Sciences and Engineering, National University of SingaporeSingapore-MIT AllianceLife Sciences Institute, National University of SingaporeDepartment of Mechanical Engineering, National University of SingaporeNanoBiomechanics Laboratory, Division of Bioengineering, National University of Singapore

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Abstract

Cancer metastasis is the main attribute to cancerrelated deaths and early detection is one of the most effective means to treat the disease. Spreading of cancer to distant sites is achieved usually through the circulatory system and the number of circulating tumor cells (CTCs) in peripheral blood is strongly associated to cancer development. Thus detecting CTCs in blood samples will be helpful in identifying susceptible subjects. Here, we propose a label-free technique to isolate these cancerous cells from blood. Using cancer cells spiked in blood samples, isolation efficiency of at least 80% were obtained with high isolation purity. The microdevice also preserved the integrity of the isolated cells to allow further studies to be done on these cells. These results showed a potential effective microdevice for CTCs studies and possible clinical application.

Keywords

Cell Isolation Microfluidics Circulating Tumor Cells Cancer Metastasis Computational Fluid Dynamics (CFD)