Modelling Dynamics in Processes and Systems

Volume 180 of the series Studies in Computational Intelligence pp 119-135

Ensemble Modeling for Bio-medical Applications

  • Christian MerkwirthAffiliated withDepartment of Information Technologies, Jagiellonian University
  • , Jörg WichardAffiliated withInstitute of Molecular PharmacologyInstitut für Medizinische Informatik
  • , Maciej J. OgorzałekAffiliated withDepartment of Information Technologies, Jagiellonian UniversityAGH University of Science and Technology

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In this paper we propose to use ensembles of models constructed using methods of Statistical Learning. The input data for model construction consists of real measurements taken in physical system under consideration. Further we propose a program toolbox which allows the construction of single models as well as heterogenous ensembles of linear and nonlinear models types. Several well performing model types, among which are ridge regression, k-nearest neighbor models and neural networks have been implemented. Ensembles of heterogenous models typically yield a better generalization performance than homogenous ensembles. Additionally given are methods for model validation and assessment as well as adaptor classes performing transparent feature selection or random subspace training on large number of input variables. The toolbox is implemented in Matlab and C++ and available under the GPL. Several applications of the described methods and the numerical toolbox itself are described. These include ECG modeling, classification of activity in drug design and ...