Combination of Intraoperative 5-Aminolevulinic Acid-Induced Fluorescence and 3-D MR Imaging for Guidance of Robotic Laser Ablation for Precision Neurosurgery

  • Hongen Liao
  • Koji Shimaya
  • Kaimeng Wang
  • Takashi Maruyama
  • Masafumi Noguchi
  • Yoshihiro Muragaki
  • Etsuko Kobayashi
  • Hiroshi Iseki
  • Ichiro Sakuma
Conference paper

DOI: 10.1007/978-3-540-85990-1_45

Part of the Lecture Notes in Computer Science book series (LNCS, volume 5242)
Cite this paper as:
Liao H. et al. (2008) Combination of Intraoperative 5-Aminolevulinic Acid-Induced Fluorescence and 3-D MR Imaging for Guidance of Robotic Laser Ablation for Precision Neurosurgery. In: Metaxas D., Axel L., Fichtinger G., Székely G. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2008. MICCAI 2008. Lecture Notes in Computer Science, vol 5242. Springer, Berlin, Heidelberg

Abstract

A combination of 5-aminolevulinic acid (5-ALA)-induced fluorescence and three-dimensional (3-D) magnetic resonance imaging (MRI) of a brain tumor has been incorporated into a robotic laser ablation neurosurgery system. 5-ALA is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent protoporphyrins IX (PpIX) in malignant glioma. The PpIX tends to accumulate in pathological lesions, and emits red fluorescence when excited by blue light. This fluorescence is illuminated with laser excitation, enables intra-operative identification of the position of a tumor and provides guidance for resection with laser photocoagulation. The information provided by the MRI is enhanced by the 5-ALA fluorescence data, and this enhanced information is integrated into a robotic laser ablation system. The accuracy of the fluorescent measurement of the tumor is improved using high-precision spectral analysis. The fluorescence assists in the detection of malignant brain tumors intraoperatively and improves their removal rate.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Hongen Liao
    • 1
    • 2
  • Koji Shimaya
    • 1
  • Kaimeng Wang
    • 1
  • Takashi Maruyama
    • 3
  • Masafumi Noguchi
    • 1
  • Yoshihiro Muragaki
    • 3
  • Etsuko Kobayashi
    • 1
  • Hiroshi Iseki
    • 3
  • Ichiro Sakuma
    • 1
  1. 1.Graduate School of Engineeringthe University of Tokyo 
  2. 2.Translational Systems Biology and Medicine InitiativeThe University of TokyoTokyoJapan
  3. 3.Graduate School of MedicineTokyo Women’s Medical UniversityTokyoJapan

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