Reconstructing Metabolic Pathways by Bidirectional Chemical Search
- Cite this paper as:
- Félix L., Rosselló F., Valiente G. (2007) Reconstructing Metabolic Pathways by Bidirectional Chemical Search. In: Calder M., Gilmore S. (eds) Computational Methods in Systems Biology. CMSB 2007. Lecture Notes in Computer Science, vol 4695. Springer, Berlin, Heidelberg
One of the main challenges in systems biology is the establishment of the metabolome: a catalogue of the metabolites and biochemical reactions present in a specific organism. Current knowledge of biochemical pathways as stored in public databases such as KEGG, is based on carefully curated genomic evidence for the presence of specific metabolites and enzymes that activate particular biochemical reactions. In this paper, we present an efficient method to build a substantial portion of the artificial chemistry defined by the metabolites and biochemical reactions in a given metabolic pathway, which is based on bidirectional chemical search. Computational results on the pathways stored in KEGG reveal novel biochemical pathways.
KeywordsArtificial chemistry biochemical reaction metabolic pathway
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