The Role of a Priori Information in the Minimization of Contact Potentials by Means of Estimation of Distribution Algorithms
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- Santana R., Larrañaga P., Lozano J.A. (2007) The Role of a Priori Information in the Minimization of Contact Potentials by Means of Estimation of Distribution Algorithms. In: Marchiori E., Moore J.H., Rajapakse J.C. (eds) Evolutionary Computation,Machine Learning and Data Mining in Bioinformatics. EvoBIO 2007. Lecture Notes in Computer Science, vol 4447. Springer, Berlin, Heidelberg
Directed search methods and probabilistic approaches have been used as two alternative ways for computational protein design. This paper presents a hybrid methodology that combines features from both approaches. Three estimation of distribution algorithms are applied to the solution of a protein design problem by minimization of contact potentials. The combination of probabilistic models able to represent probabilistic dependencies with the use of information about residues interactions in the protein contact graph is shown to improve the efficiency of search for the problems evaluated.
Keywordsestimation of distribution algorithm protein design energy minimization algorithms.
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